Entity Details

Primary name TNFB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01374
EntryNameTNFB_HUMAN
FullNameLymphotoxin-alpha
TaxID9606
Evidenceevidence at protein level
Length205
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLTA

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007584 response to nutrient
GO:0032496 response to lipopolysaccharide
GO:0032729 positive regulation of interferon-gamma production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0048147 negative regulation of fibroblast proliferation
GO:0048535 lymph node development
GO:0050830 defense response to Gram-positive bacterium
GO:0060252 positive regulation of glial cell proliferation

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR002960 Lymphotoxin-alphaFamilyFamily
IPR006052 Tumour necrosis factor domainDomainDomain
IPR006053 Tumour necrosis factorFamilyFamily
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00005 EtanerceptDrugbankbiotech

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink