Entity Details

Primary name CD4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01730
EntryNameCD4_HUMAN
FullNameT-cell surface glycoprotein CD4
TaxID9606
Evidenceevidence at protein level
Length458
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCD4

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0004888 transmembrane signaling receptor activity
GO:0005201 extracellular matrix structural constituent
GO:0005769 early endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006948 induction by virus of host cell-cell fusion
GO:0006955 immune response
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0015026 coreceptor activity
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019865 immunoglobulin binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0023026 MHC class II protein complex binding
GO:0030217 T cell differentiation
GO:0030225 macrophage differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032355 response to estradiol
GO:0032507 maintenance of protein location in cell
GO:0032743 positive regulation of interleukin-2 production
GO:0033280 response to vitamin D
GO:0033674 positive regulation of kinase activity
GO:0035397 helper T cell enhancement of adaptive immune response
GO:0035723 interleukin-15-mediated signaling pathway
GO:0038023 signaling receptor activity
GO:0042011 interleukin-16 binding
GO:0042012 interleukin-16 receptor activity
GO:0042101 T cell receptor complex
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0042289 MHC class II protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410 positive regulation of MAPK cascade
GO:0044409 entry into host
GO:0045058 T cell selection
GO:0045121 membrane raft
GO:0045657 positive regulation of monocyte differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046598 positive regulation of viral entry into host cell
GO:0050690 regulation of defense response to virus by virus
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050829 defense response to Gram-negative bacterium
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050863 regulation of T cell activation
GO:0051924 regulation of calcium ion transport
GO:0061024 membrane organization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000973 T-cell surface antigen CD4FamilyFamily
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008424 Immunoglobulin C2-setDomainDomain
IPR013106 Immunoglobulin V-set domainDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015274 CD4, extracellularDomainDomain
IPR021963 T cell CD4 receptor C-terminal regionDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB06241 ClenoliximabDrugbankbiotech
DB12698 IbalizumabDrugbankbiotech

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CD4_HUMANLCK_MOUSEBioGRID1835265 details