Entity Details

Primary name HLAB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01889
EntryNameHLAB_HUMAN
FullNameHLA class I histocompatibility antigen, B alpha chain
TaxID9606
Evidenceevidence at protein level
Length362
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHLA-B

GO terms

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GOName
GO:0005886 plasma membrane
GO:0006955 immune response
GO:0030670 phagocytic vesicle membrane
GO:0032675 regulation of interleukin-6 production
GO:0042612 MHC class I protein complex
GO:0043312 neutrophil degranulation
GO:0051087 chaperone binding
GO:0070062 extracellular exosome
GO:2001198 regulation of dendritic cell differentiation
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0050776 regulation of immune response
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0031901 early endosome membrane
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042605 peptide antigen binding
GO:0046977 TAP binding
GO:0060337 type I interferon signaling pathway
GO:0000139 Golgi membrane
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002667 regulation of T cell anergy
GO:0005887 integral component of plasma membrane
GO:0006952 defense response
GO:0009986 cell surface
GO:0016020 membrane
GO:0030667 secretory granule membrane
GO:0032655 regulation of interleukin-12 production
GO:0055038 recycling endosome membrane

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01048 AbacavirDrugbanksmall molecule
DB04464 N-FormylmethionineDrugbanksmall molecule
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink