Entity Details

Primary name LMNA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02545
EntryNameLMNA_HUMAN
FullNamePrelamin-A/C
TaxID9606
Evidenceevidence at protein level
Length664
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesLMNA

GO terms

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GOName
GO:0005198 structural molecule activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005638 lamin filament
GO:0005652 nuclear lamina
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0006998 nuclear envelope organization
GO:0007084 mitotic nuclear membrane reassembly
GO:0007517 muscle organ development
GO:0008285 negative regulation of cell population proliferation
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0030334 regulation of cell migration
GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
GO:0031965 nuclear membrane
GO:0032204 regulation of telomere maintenance
GO:0034504 protein localization to nucleus
GO:0034613 cellular protein localization
GO:0035861 site of double-strand break
GO:0036498 IRE1-mediated unfolded protein response
GO:0042802 identical protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0071456 cellular response to hypoxia
GO:0090343 positive regulation of cell aging
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:1990683 DNA double-strand break attachment to nuclear envelope

Subcellular Location

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Subcellular Location
Nucleus
Nucleus envelope
Nucleus lamina
Nucleus matrix
Nucleus speckle

Domains

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DomainNameCategoryType
IPR001322 Lamin tail domainDomainDomain
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR036415 Lamin tail domain superfamilyFamilyHomologous superfamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Interactions

3 interactions