Entity Details

Primary name SRC_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP05480
EntryNameSRC_MOUSE
FullNameNeuronal proto-oncogene tyrosine-protein kinase Src
TaxID10090
Evidenceevidence at protein level
Length535
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesSrc

GO terms

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GOName
GO:0001545 primary ovarian follicle growth
GO:0001819 positive regulation of cytokine production
GO:0002102 podosome
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005102 signaling receptor binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0010447 response to acidic pH
GO:0010628 positive regulation of gene expression
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010907 positive regulation of glucose metabolic process
GO:0010954 positive regulation of protein processing
GO:0014069 postsynaptic density
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016004 phospholipase activator activity
GO:0016020 membrane
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0020037 heme binding
GO:0022407 regulation of cell-cell adhesion
GO:0030054 cell junction
GO:0030154 cell differentiation
GO:0030331 estrogen receptor binding
GO:0030900 forebrain development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0031667 response to nutrient levels
GO:0031954 positive regulation of protein autophosphorylation
GO:0032148 activation of protein kinase B activity
GO:0032211 negative regulation of telomere maintenance via telomerase
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034332 adherens junction organization
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0035306 positive regulation of dephosphorylation
GO:0035556 intracellular signal transduction
GO:0036035 osteoclast development
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042169 SH2 domain binding
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043274 phospholipase binding
GO:0043393 regulation of protein binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 transmembrane transporter binding
GO:0044877 protein-containing complex binding
GO:0045056 transcytosis
GO:0045087 innate immune response
GO:0045453 bone resorption
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045747 positive regulation of Notch signaling pathway
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050847 progesterone receptor signaling pathway
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051219 phosphoprotein binding
GO:0051222 positive regulation of protein transport
GO:0051385 response to mineralocorticoid
GO:0051602 response to electrical stimulus
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051902 negative regulation of mitochondrial depolarization
GO:0051974 negative regulation of telomerase activity
GO:0060065 uterus development
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060491 regulation of cell projection assembly
GO:0060576 intestinal epithelial cell development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070555 response to interleukin-1
GO:0070700 BMP receptor binding
GO:0070851 growth factor receptor binding
GO:0071222 cellular response to lipopolysaccharide
GO:0071253 connexin binding
GO:0071375 cellular response to peptide hormone stimulus
GO:0071393 cellular response to progesterone stimulus
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071498 cellular response to fluid shear stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071803 positive regulation of podosome assembly
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0086098 angiotensin-activated signaling pathway involved in heart process
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097110 scaffold protein binding
GO:0098609 cell-cell adhesion
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:1900182 positive regulation of protein localization to nucleus
GO:1902533 positive regulation of intracellular signal transduction
GO:2000386 positive regulation of ovarian follicle development
GO:2000394 positive regulation of lamellipodium morphogenesis
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO:2000641 regulation of early endosome to late endosome transport
GO:2000811 negative regulation of anoikis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001286 regulation of caveolin-mediated endocytosis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Mitochondrion inner membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

63 interactions

InteractorPartnerSourcesPublicationsLink
SRC_MOUSEKPCE_MOUSEBioGRID, IntAct11139474 11834516 details
SRC_MOUSEFAK1_HUMANMINT18560762 21266176 details
SRC_MOUSEPTPRA_MOUSEMINT7518772 details
SRC_MOUSEROR1_HUMANIntAct22439932 details
SRC_MOUSEITB3_HUMANmbinfo14593208 details
SRC_MOUSEPAXI_HUMANmbinfo16478788 details
SRC_MOUSEPAXI_MOUSEBioGRID, mbinfo14636584 16478788 details
SRC_MOUSEFRS2_MOUSEIntAct23452850 details
SRC_MOUSEHXK1_HUMANIntAct28054552 details
SRC_MOUSEHXK2_HUMANIntAct28054552 details
SRC_MOUSETRPC1_MOUSEDIP16407161 details
SRC_MOUSETRPC3_HUMANDIP16407161 details
SRC_MOUSETRPC6_MOUSEDIP16407161 details
SRC_MOUSETRPC5_MOUSEDIP16407161 details
SRC_MOUSETRPC2_MOUSEDIP16407161 details
SRC_MOUSETRPC4_MOUSEDIP16407161 details
SRC_MOUSECBL_MOUSEBioGRID, DIP11804588 17420256 22138575 32325033 8635998 8849724 9013636 details
SRC_MOUSEDVL2_MOUSEBioGRID19920076 details
SRC_MOUSEKHDR1_MOUSEBioGRID10844001 15890643 details
SRC_MOUSEENOA_MOUSEBioGRID14739300 9013636 details
SRC_MOUSESRC_MOUSEBioGRID10684249 17135401 details
SRC_MOUSECASB_MOUSEBioGRID10684249 details
SRC_MOUSEP3C2A_MOUSEBioGRID10684249 details
SRC_MOUSEEFS_MOUSEBioGRID8647432 details
SRC_MOUSEKAPCA_MOUSEBioGRID11804588 details
SRC_MOUSEENAH_MOUSEBioGRID8861907 details
SRC_MOUSEFAK1_MOUSEBioGRID, MINT10362356 10931187 16966330 18233957 32325033 details
SRC_MOUSENMDE2_MOUSEBioGRID, IntAct10862698 16635246 details
SRC_MOUSEDOK2_MOUSEMINT15831486 details
SRC_MOUSEPDC6I_MOUSEMINT15557335 details
SRC_MOUSECSF1_MOUSEIntAct16267818 details
SRC_MOUSEEPHB2_MOUSEIntAct16298995 details
SRC_MOUSE5HT4R_MOUSEMINT19661922 details
SRC_MOUSEWASP_MOUSEMolecular Connections18289379 details
SRC_MOUSECSF1R_HUMANMINT7730365 details
SRC_MOUSERET_MOUSEMINT22732841 details
SRC_MOUSEMLP3B_MOUSEBioGRID, DIP, MINT22138575 22732841 details
SRC_MOUSECSF1R_MOUSEBioGRID, DIP17420256 18840695 32325033 details
SRC_MOUSEITB3_MOUSEDIP18840695 details
SRC_MOUSEAKT1_MOUSEBioGRID, DIP19122674 details
SRC_MOUSECXA1_MOUSEBioGRID, DIP21282606 32325033 details
SRC_MOUSESKP2_MOUSEBioGRID20596523 details
SRC_MOUSES1PR1_MOUSEBioGRID21102457 details
SRC_MOUSEJAK2_MOUSEBioGRID21102457 details
SRC_MOUSEFAK2_MOUSEBioGRID11274221 14739300 details
SRC_MOUSESHIP1_MOUSEBioGRID16601135 details
SRC_MOUSEDIAP1_MOUSEBioGRID18194650 details
SRC_MOUSEVGFR2_MOUSEBioGRID16966330 18194650 details
SRC_MOUSEEGFR_MOUSEBioGRID11274221 details
SRC_MOUSECAV3_MOUSEBioGRID14600260 8663016 details
SRC_MOUSEDAB1_MOUSEBioGRID15062102 details
SRC_MOUSEGAB1_MOUSEBioGRID12808090 details
SRC_MOUSEESR1_MOUSEBioGRID17921256 details
SRC_MOUSESHC1_MOUSEBioGRID15716419 details
SRC_MOUSESHC2_MOUSEBioGRID15716419 details
SRC_MOUSESHC3_MOUSEBioGRID15716419 details
SRC_MOUSEATX2_MOUSEBioGRID18602463 details
SRC_MOUSEARRB1_MOUSEBioGRID19122674 32325033 details
SRC_MOUSEARRB2_MOUSEBioGRID19122674 details
SRC_MOUSEBCAR1_MOUSEBioGRID11038351 details
SRC_MOUSEITA2_MOUSEBioGRID11038351 details
SRC_MOUSEEP300_MOUSEBioGRID26695438 details
SRC_MOUSEHCN2_MOUSEBioGRID16079136 32325033 details