Entity Details

Primary name FINC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02751
EntryNameFINC_HUMAN
FullNameFibronectin
TaxID9606
Evidenceevidence at protein level
Length2477
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesFN1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001932 regulation of protein phosphorylation
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0006953 acute-phase response
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007399 nervous system development
GO:0007507 heart development
GO:0008022 protein C-terminus binding
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016324 apical plasma membrane
GO:0016504 peptidase activator activity
GO:0018149 peptide cross-linking
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0033622 integrin activation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035987 endodermal cell differentiation
GO:0042802 identical protein binding
GO:0043394 proteoglycan binding
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045773 positive regulation of axon extension
GO:0048146 positive regulation of fibroblast proliferation
GO:0050900 leukocyte migration
GO:0051087 chaperone binding
GO:0051702 biological process involved in interaction with symbiont
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071635 negative regulation of transforming growth factor beta production
GO:0072378 blood coagulation, fibrin clot formation
GO:0072562 blood microparticle
GO:0097718 disordered domain specific binding
GO:1901166 neural crest cell migration involved in autonomic nervous system development
GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000083 Fibronectin, type IDomainDomain
IPR000562 Fibronectin type II domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB06245 LanoteplaseDrugbankbiotech
DB08888 OcriplasminDrugbankbiotech
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink