Entity Details

Primary name TTHY_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02766
EntryNameTTHY_HUMAN
FullNameTransthyretin
TaxID9606
Evidenceevidence at protein level
Length147
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTTR

GO terms

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GOName
GO:0001523 retinoid metabolic process
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006144 purine nucleobase metabolic process
GO:0030198 extracellular matrix organization
GO:0032991 protein-containing complex
GO:0035578 azurophil granule lumen
GO:0042572 retinol metabolic process
GO:0042802 identical protein binding
GO:0043312 neutrophil degranulation
GO:0044877 protein-containing complex binding
GO:0070062 extracellular exosome
GO:0070324 thyroid hormone binding
GO:0070327 thyroid hormone transport
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000895 Transthyretin/hydroxyisourate hydrolaseFamilyFamily
IPR023416 Transthyretin/hydroxyisourate hydrolase domainDomainDomain
IPR023418 Transthyretin, thyroxine binding siteSiteBinding site
IPR023419 Transthyretin, conserved siteSiteConserved site
IPR030178 TransthyretinFamilyFamily
IPR036817 Transthyretin/hydroxyisourate hydrolase domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00861 DiflunisalDrugbanksmall molecule
DB01093 Dimethyl sulfoxideSwissprotsmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01751 Tetraiodothyroacetic acidSwissprotsmall molecule
DB01838 6,4'-Dihydroxy-3-Methyl-3',5'-DibromoflavoneSwissprotsmall molecule
DB02179 O-Trifluoromethylphenyl Anthranilic AcidSwissprotsmall molecule
DB02266 Flufenamic acidDrugbanksmall molecule
DB02417 2,4,6-TribromophenolSwissprotsmall molecule
DB02698 N-(M-Trifluoromethylphenyl) Phenoxazine-4,6-Dicarboxylic AcidSwissprotsmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03167 PentabromophenolSwissprotsmall molecule
DB03239 3',5'-Dinitro-N-Acetyl-L-ThyronineSwissprotsmall molecule
DB03346 3,3',5,5'-tetrachlorobiphenyl-4,4'-diolDrugbanksmall molecule
DB03682 Dibenzofuran-4,6-Dicarboxylic AcidSwissprotsmall molecule
DB04474 8-anilinonaphthalene-1-sulfonic acidDrugbanksmall molecule
DB04674 2-HYDROXY-3,5-DIIODOBENZOIC ACIDDrugbanksmall molecule
DB04756 2-[(3,5-Dichloro-4-trioxidanylphenyl)amino]benzoic acidSwissprotsmall molecule
DB05235 NRP409Drugbanksmall molecule
DB05352 Fx-1006ASwissprotsmall molecule
DB06885 3-[({(1E)-[2-(trifluoromethyl)phenyl]methylidene}amino)oxy]propanoic acidSwissprotsmall molecule
DB06907 2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACIDSwissprotsmall molecule
DB06935 2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSwissprotsmall molecule
DB07047 2',4'-DICHLORO-4-HYDROXY-1,1'-BIPHENYL-3-CARBOXYLIC ACIDSwissprotsmall molecule
DB07176 1-Naphthylamine-5-sulfonic acidSwissprotsmall molecule
DB07201 (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acidSwissprotsmall molecule
DB07240 3-[(9H-fluoren-9-ylideneamino)oxy]propanoic acidSwissprotsmall molecule
DB07282 3-({[(1Z)-(2-methoxyphenyl)methylidene]amino}oxy)propanoic acidSwissprotsmall molecule
DB07693 N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamideSwissprotsmall molecule
DB07694 2,5-dichloro-N-(3,5-dibromo-4-hydroxyphenyl)benzamideSwissprotsmall molecule
DB07695 N-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-3,5-dimethylbenzamideSwissprotsmall molecule
DB07753 3',5'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACIDSwissprotsmall molecule
DB07775 3',5'-DIBROMO-2',4,4',6'-TETRAHYDROXY AURONESwissprotsmall molecule
DB07962 METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATESwissprotsmall molecule
DB07963 N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINESwissprotsmall molecule
DB08100 2,6-dimethyl-4-[(E)-2-phenylethenyl]phenolSwissprotsmall molecule
DB08101 2,6-dibromo-4-[(E)-2-phenylethenyl]phenolSwissprotsmall molecule
DB08102 3,5-dibromobiphenyl-4-olSwissprotsmall molecule
DB08103 2,6-dibromo-4-phenoxyphenolSwissprotsmall molecule
DB08104 N-(3,5-dibromo-4-hydroxyphenyl)benzamideSwissprotsmall molecule
DB08205 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIMETHYLPHENOLSwissprotsmall molecule
DB08206 4-(1,3-BENZOXAZOL-2-YL)-2,6-DIBROMOPHENOLSwissprotsmall molecule
DB08207 2-(3,5-DIMETHYLPHENYL)-1,3-BENZOXAZOLESwissprotsmall molecule
DB09100 Thyroid, porcineDrugbankbiotech
DB09130 CopperDrugbanksmall molecule
DB11644 TafamidisDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

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