Entity Details

Primary name PLF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02776
EntryNamePLF4_HUMAN
FullNamePlatelet factor 4
TaxID9606
Evidenceevidence at protein level
Length101
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPF4

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008009 chemokine activity
GO:0008201 heparin binding
GO:0010628 positive regulation of gene expression
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0020005 symbiont-containing vacuole membrane
GO:0030168 platelet activation
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031093 platelet alpha granule lumen
GO:0031640 killing of cells of other organism
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042127 regulation of cell population proliferation
GO:0042832 defense response to protozoan
GO:0045236 CXCR chemokine receptor binding
GO:0045347 negative regulation of MHC class II biosynthetic process
GO:0045651 positive regulation of macrophage differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045653 negative regulation of megakaryocyte differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048248 CXCR3 chemokine receptor binding
GO:0051873 killing by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070098 chemokine-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001089 CXC chemokineFamilyFamily
IPR001811 Chemokine interleukin-8-like domainDomainDomain
IPR018048 CXC chemokine, conserved siteSiteConserved site
IPR027222 Platelet factor 4FamilyFamily
IPR033899 CXC Chemokine domainDomainDomain
IPR036048 Chemokine interleukin-8-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00055 Drotrecogin alfaDrugbankbiotech
DB01109 HeparinDrugbanksmall molecule

Interactions

0 interactions

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