Entity Details

Primary name TFR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02786
EntryNameTFR1_HUMAN
FullNameTransferrin receptor protein 1
TaxID9606
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTFRC

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004998 transferrin receptor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0008235 metalloexopeptidase activity
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010637 negative regulation of mitochondrial fusion
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0019901 protein kinase binding
GO:0030316 osteoclast differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033572 transferrin transport
GO:0035556 intracellular signal transduction
GO:0035690 cellular response to drug
GO:0042102 positive regulation of T cell proliferation
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044877 protein-containing complex binding
GO:0045780 positive regulation of bone resorption
GO:0045830 positive regulation of isotype switching
GO:0048471 perinuclear region of cytoplasm
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055037 recycling endosome
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0150104 transport across blood-brain barrier
GO:1900182 positive regulation of protein localization to nucleus
GO:1903561 extracellular vesicle
GO:1990712 HFE-transferrin receptor complex
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Subcellular Location
Cell membrane
Melanosome
Secreted

Domains

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DomainNameCategoryType
IPR003137 PA domainDomainDomain
IPR007365 Transferrin receptor-like, dimerisation domainDomainDomain
IPR007484 Peptidase M28DomainDomain
IPR029513 Transferrin receptor protein 1FamilyFamily
IPR036757 Transferrin receptor-like, dimerisation domain superfamilyFamilyHomologous superfamily
IPR037324 Transferrin receptor protein 1/2, PA domainDomainDomain
IPR039373 Glutamate carboxypeptidase 2-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01592 IronDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB06784 Gallium citrate Ga-67Swissprotsmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB15617 Ferric derisomaltoseDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TFR1_HUMANNUMB_MOUSEIntAct23211419 details