Entity Details

Primary name TRFE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02787
EntryNameTRFE_HUMAN
FullNameSerotransferrin
TaxID9606
Evidenceevidence at protein level
Length698
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesTF

GO terms

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GOName
GO:0001895 retina homeostasis
GO:0002576 platelet degranulation
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006826 iron ion transport
GO:0006879 cellular iron ion homeostasis
GO:0007015 actin filament organization
GO:0007257 obsolete activation of JUN kinase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016324 apical plasma membrane
GO:0019731 antibacterial humoral response
GO:0030139 endocytic vesicle
GO:0030316 osteoclast differentiation
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031232 extrinsic component of external side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031647 regulation of protein stability
GO:0031982 vesicle
GO:0033572 transferrin transport
GO:0034756 regulation of iron ion transport
GO:0034774 secretory granule lumen
GO:0034986 iron chaperone activity
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045178 basal part of cell
GO:0045780 positive regulation of bone resorption
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055072 iron ion homeostasis
GO:0060395 SMAD protein signal transduction
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070371 ERK1 and ERK2 cascade
GO:0071281 cellular response to iron ion
GO:0072562 blood microparticle
GO:1990459 transferrin receptor binding
GO:1990712 HFE-transferrin receptor complex
GO:2000147 positive regulation of cell motility

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001156 Transferrin-like domainDomainDomain
IPR016357 TransferrinFamilyFamily
IPR018195 Transferrin family, iron binding siteSiteBinding site
IPR030685 Serotransferrin, mammalianFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00515 CisplatinDrugbanksmall molecule
DB00677 IsoflurophateDrugbanksmall molecule
DB00893 Iron DextranDrugbanksmall molecule
DB01294 Bismuth subsalicylateSwissprotsmall molecule
DB01370 AluminiumDrugbanksmall molecule
DB01592 IronDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB05260 Gallium nitrateDrugbanksmall molecule
DB06215 FerumoxytolSwissprotsmall molecule
DB06757 ManganeseDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11136 ChromiumDrugbanksmall molecule
DB11182 Rose bengalSwissprotsmall molecule
DB11397 DichlorvosDrugbanksmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14488 Ferrous gluconateDrugbanksmall molecule
DB14489 Ferrous succinateDrugbanksmall molecule
DB14490 Ferrous ascorbateDrugbanksmall molecule
DB14491 Ferrous fumarateDrugbanksmall molecule
DB14501 Ferrous glycine sulfateDrugbanksmall molecule
DB14517 Aluminium phosphateDrugbanksmall molecule
DB14518 Aluminum acetateDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB14526 Chromic citrateDrugbanksmall molecule
DB14527 Chromic nitrateDrugbanksmall molecule
DB14528 Chromium gluconateDrugbanksmall molecule
DB14529 Chromium nicotinateDrugbanksmall molecule
DB14530 Chromous sulfateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TRFE_HUMANCPNE6_MOUSEMINT21087455 details