Entity Details

Primary name ESR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP03372
EntryNameESR1_HUMAN
FullNameEstrogen receptor
TaxID9606
Evidenceevidence at protein level
Length595
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesESR1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001093 TFIIB-class transcription factor binding
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001547 antral ovarian follicle growth
GO:0002064 epithelial cell development
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008209 androgen metabolic process
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016579 protein deubiquitination
GO:0017025 TBP-class protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030235 nitric-oxide synthase regulator activity
GO:0030284 estrogen receptor activity
GO:0030331 estrogen receptor binding
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0032355 response to estradiol
GO:0032991 protein-containing complex
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0034056 estrogen response element binding
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0035327 transcriptionally active chromatin
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043627 response to estrogen
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048146 positive regulation of fibroblast proliferation
GO:0048863 stem cell differentiation
GO:0050727 regulation of inflammatory response
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051117 ATPase binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060065 uterus development
GO:0060068 vagina development
GO:0060523 prostate epithelial cord elongation
GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687 regulation of branching involved in prostate gland morphogenesis
GO:0060745 mammary gland branching involved in pregnancy
GO:0060749 mammary gland alveolus development
GO:0060750 epithelial cell proliferation involved in mammary gland duct elongation
GO:0071168 protein localization to chromatin
GO:0071391 cellular response to estrogen stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0097550 transcription preinitiation complex
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001292 Estrogen receptorFamilyFamily
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR024178 Estrogen receptor/oestrogen-related receptorFamilyFamily
IPR024736 Oestrogen-type nuclear receptor final C-terminal domainDomainDomain
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00255 DiethylstilbestrolDrugbanksmall molecule
DB00269 ChlorotrianiseneDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00304 DesogestrelDrugbanksmall molecule
DB00367 LevonorgestrelDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00539 ToremifeneDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00648 MitotaneDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00756 HexachloropheneDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00823 Ethynodiol diacetateDrugbanksmall molecule
DB00841 DobutamineDrugbanksmall molecule
DB00882 ClomifeneDrugbanksmall molecule
DB00890 DienestrolDrugbanksmall molecule
DB00947 FulvestrantDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01108 TrilostaneDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01185 FluoxymesteroneDrugbanksmall molecule
DB01196 EstramustineDrugbanksmall molecule
DB01357 MestranolDrugbanksmall molecule
DB01406 DanazolDrugbanksmall molecule
DB01428 OxybenzoneDrugbanksmall molecule
DB01431 AllylestrenolDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01708 PrasteroneDrugbanksmall molecule
DB01878 BenzophenoneDrugbanksmall molecule
DB02187 EquilinDrugbanksmall molecule
DB02615 Compound 19Drugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB02715 Compound 18Drugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB02757 PyrazoleDrugbanksmall molecule
DB02901 StanoloneDrugbanksmall molecule
DB03467 NaringeninDrugbanksmall molecule
DB03742 Compound 4-DDrugbanksmall molecule
DB03802 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-OlDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04468 AfimoxifeneDrugbanksmall molecule
DB04471 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-OlDrugbanksmall molecule
DB04573 EstriolDrugbanksmall molecule
DB04574 Estrone sulfateDrugbanksmall molecule
DB04575 QuinestrolDrugbanksmall molecule
DB04824 PhenolphthaleinDrugbanksmall molecule
DB04930 PermethrinDrugbanksmall molecule
DB04938 OspemifeneDrugbanksmall molecule
DB05233 AP1081Drugbanksmall molecule
DB05487 CustirsenDrugbanksmall molecule
DB05662 NP-50301Drugbanksmall molecule
DB05882 CHF 4227Drugbanksmall molecule
DB05966 TAS-108Drugbanksmall molecule
DB06202 LasofoxifeneDrugbanksmall molecule
DB06249 ArzoxifeneDrugbanksmall molecule
DB06374 ElacestrantDrugbanksmall molecule
DB06401 BazedoxifeneDrugbanksmall molecule
DB06710 MethyltestosteroneDrugbanksmall molecule
DB06732 beta-NaphthoflavoneDrugbanksmall molecule
DB06871 17-METHYL-17-ALPHA-DIHYDROEQUILENINDrugbanksmall molecule
DB06898 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenolDrugbanksmall molecule
DB06927 [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILEDrugbanksmall molecule
DB07086 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07087 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07195 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB07567 (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OLDrugbanksmall molecule
DB07638 (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB07678 (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07707 (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOLDrugbanksmall molecule
DB07708 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07712 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OLDrugbanksmall molecule
DB07931 HexestrolDrugbanksmall molecule
DB07932 dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylateDrugbanksmall molecule
DB07933 ErteberelDrugbanksmall molecule
DB07991 N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDEDrugbanksmall molecule
DB08020 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OLDrugbanksmall molecule
DB08047 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diolDrugbanksmall molecule
DB08048 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB08320 DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATEDrugbanksmall molecule
DB08398 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridineDrugbanksmall molecule
DB08595 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOLDrugbanksmall molecule
DB08737 (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OLDrugbanksmall molecule
DB08773 2-(4-hydroxyphenyl)benzo[b]thiophen-6-olDrugbanksmall molecule
DB09070 TiboloneDrugbanksmall molecule
DB09086 EugenolDrugbanksmall molecule
DB09317 Synthetic Conjugated Estrogens, ADrugbanksmall molecule
DB09318 Synthetic Conjugated Estrogens, BDrugbanksmall molecule
DB09369 Polyestradiol phosphateDrugbanksmall molecule
DB09371 NorethynodrelDrugbanksmall molecule
DB09535 OctocryleneDrugbanksmall molecule
DB11064 HomosalateDrugbanksmall molecule
DB11219 EnzacameneDrugbanksmall molecule
DB11478 ZeranolDrugbanksmall molecule
DB11541 RactopamineDrugbanksmall molecule
DB11619 GestrinoneDrugbanksmall molecule
DB12450 Propyl GallateDrugbanksmall molecule
DB13869 2-Methoxy-6-{(E)-[(4-methylphenyl)imino]methyl}phenolDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13951 Stanolone acetateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule
DB14641 Estriol tripropionateDrugbanksmall molecule
DB15690 Fluoroestradiol F-18Drugbanksmall molecule