Entity Details

Primary name RAF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04049
EntryNameRAF1_HUMAN
FullNameRAF proto-oncogene serine/threonine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length648
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesRAF1

GO terms

Show/Hide Table
GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0007190 activation of adenylate cyclase activity
GO:0007507 heart development
GO:0035019 somatic stem cell population maintenance
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0060324 face development
GO:0071550 death-inducing signaling complex assembly
GO:0106310 protein serine kinase activity
GO:2000145 regulation of cell motility
GO:0001666 response to hypoxia
GO:0005739 mitochondrion
GO:0005794 Golgi apparatus
GO:0008179 adenylate cyclase binding
GO:0030878 thyroid gland development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034220 ion transmembrane transport
GO:0035023 regulation of Rho protein signal transduction
GO:0035994 response to muscle stretch
GO:0045595 regulation of cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048538 thymus development
GO:0002250 adaptive immune response
GO:0004709 MAP kinase kinase kinase activity
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016607 nuclear speck
GO:0019899 enzyme binding
GO:0031143 pseudopodium
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0042060 wound healing
GO:0042981 regulation of apoptotic process
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell population proliferation
GO:0010856 adenylate cyclase activator activity
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0042802 identical protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045104 intermediate filament cytoskeleton organization
GO:0046872 metal ion binding
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0106311 protein threonine kinase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion
Cell membrane
Nucleus
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003116 Raf-like Ras-bindingDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB04973 LErafAONDrugbankbiotech
DB05190 XL281Drugbanksmall molecule
DB05268 iCo-007Drugbanksmall molecule
DB08862 CholecystokininDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08912 DabrafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule