Entity Details

Primary name ITAM_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP05555
EntryNameITAM_MOUSE
FullNameIntegrin alpha-M
TaxID10090
Evidenceevidence at protein level
Length1153
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GO terms

Show/Hide Table
GOName
GO:0001774 microglial cell activation
GO:0001781 neutrophil apoptotic process
GO:0001846 opsonin binding
GO:0001851 complement component C3b binding
GO:0002523 leukocyte migration involved in inflammatory response
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008201 heparin binding
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014005 microglia development
GO:0016021 integral component of membrane
GO:0030593 neutrophil chemotaxis
GO:0030900 forebrain development
GO:0031072 heat shock protein binding
GO:0032930 positive regulation of superoxide anion generation
GO:0034688 integrin alphaM-beta2 complex
GO:0038024 cargo receptor activity
GO:0043315 positive regulation of neutrophil degranulation
GO:0043395 heparan sulfate proteoglycan binding
GO:0044853 plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045123 cellular extravasation
GO:0045963 negative regulation of dopamine metabolic process
GO:0046872 metal ion binding
GO:0050798 activated T cell proliferation
GO:0060376 positive regulation of mast cell differentiation
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0090314 positive regulation of protein targeting to membrane
GO:0097190 apoptotic signaling pathway
GO:0097242 amyloid-beta clearance
GO:0098609 cell-cell adhesion
GO:0110090 positive regulation of hippocampal neuron apoptotic process
GO:0150062 complement-mediated synapse pruning
GO:0150064 vertebrate eye-specific patterning
GO:1901216 positive regulation of neuron death
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling
GO:2000363 positive regulation of prostaglandin-E synthase activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
ITAM_MOUSEITB2_MOUSEInnateDB20639876 details