Entity Details

Primary name GCR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04150
EntryNameGCR_HUMAN
FullNameGlucocorticoid receptor
TaxID9606
Evidenceevidence at protein level
Length777
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesNR3C1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001046 core promoter sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0004879 nuclear receptor activity
GO:0004883 glucocorticoid receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005759 mitochondrial matrix
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007059 chromosome segregation
GO:0007165 signal transduction
GO:0008270 zinc ion binding
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0032991 protein-containing complex
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051301 cell division
GO:0051879 Hsp90 protein binding
GO:0071383 cellular response to steroid hormone stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990239 steroid hormone binding
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001409 Glucocorticoid receptorFamilyFamily
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00180 FlunisolideDrugbanksmall molecule
DB00223 DiflorasoneDrugbanksmall molecule
DB00240 AlclometasoneDrugbanksmall molecule
DB00253 MedrysoneDrugbanksmall molecule
DB00288 AmcinonideDrugbanksmall molecule
DB00324 FluorometholoneDrugbanksmall molecule
DB00351 Megestrol acetateDrugbanksmall molecule
DB00367 LevonorgestrelDrugbanksmall molecule
DB00394 Beclomethasone dipropionateDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00443 BetamethasoneDrugbanksmall molecule
DB00547 DesoximetasoneDrugbanksmall molecule
DB00588 Fluticasone propionateDrugbanksmall molecule
DB00591 Fluocinolone acetonideDrugbanksmall molecule
DB00596 UlobetasolDrugbanksmall molecule
DB00620 TriamcinoloneDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00663 FlumethasoneDrugbanksmall molecule
DB00687 FludrocortisoneDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00764 MometasoneDrugbanksmall molecule
DB00769 HydrocortamateDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00838 ClocortoloneDrugbanksmall molecule
DB00846 FlurandrenolideDrugbanksmall molecule
DB00860 PrednisoloneDrugbanksmall molecule
DB00896 RimexoloneDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01013 Clobetasol propionateDrugbanksmall molecule
DB01047 FluocinonideDrugbanksmall molecule
DB01130 PrednicarbateDrugbanksmall molecule
DB01185 FluoxymesteroneDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01260 DesonideDrugbanksmall molecule
DB01380 Cortisone acetateDrugbanksmall molecule
DB01384 ParamethasoneDrugbanksmall molecule
DB01395 DrospirenoneDrugbanksmall molecule
DB01410 CiclesonideDrugbanksmall molecule
DB02210 Hexane-1,6-DiolDrugbanksmall molecule
DB04630 AldosteroneDrugbanksmall molecule
DB05423 ORG-34517Drugbanksmall molecule
DB06781 DifluprednateDrugbanksmall molecule
DB08867 UlipristalDrugbanksmall molecule
DB08906 Fluticasone furoateDrugbanksmall molecule
DB09091 TixocortolDrugbanksmall molecule
DB09095 DifluocortoloneDrugbanksmall molecule
DB11619 GestrinoneDrugbanksmall molecule
DB11921 DeflazacortDrugbanksmall molecule
DB12637 OnapristoneDrugbanksmall molecule
DB13003 CortivazolDrugbanksmall molecule
DB13158 ClobetasoneDrugbanksmall molecule
DB13867 FluticasoneDrugbanksmall molecule
DB14512 Mometasone furoateDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14583 Segesterone acetateDrugbanksmall molecule
DB14596 Loteprednol etabonateDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14669 Betamethasone phosphateDrugbanksmall molecule
DB15566 Prednisolone acetateDrugbanksmall molecule

Interactions

4 interactions