Entity Details

Primary name JUN_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP05627
EntryNameJUN_MOUSE
FullNameTranscription factor AP-1
TaxID10090
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesJun

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001774 microglial cell activation
GO:0001836 release of cytochrome c from mitochondria
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0003151 outflow tract morphogenesis
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009314 response to radiation
GO:0009987 cellular process
GO:0010634 positive regulation of epithelial cell migration
GO:0017053 transcription repressor complex
GO:0019899 enzyme binding
GO:0030224 monocyte differentiation
GO:0031103 axon regeneration
GO:0031625 ubiquitin protein ligase binding
GO:0031953 negative regulation of protein autophosphorylation
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0034614 cellular response to reactive oxygen species
GO:0035026 leading edge cell differentiation
GO:0035497 cAMP response element binding
GO:0035976 transcription factor AP-1 complex
GO:0035994 response to muscle stretch
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0044389 ubiquitin-like protein ligase binding
GO:0044877 protein-containing complex binding
GO:0045657 positive regulation of monocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048146 positive regulation of fibroblast proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051365 cellular response to potassium ion starvation
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0051899 membrane depolarization
GO:0060395 SMAD protein signal transduction
GO:0061029 eyelid development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070412 R-SMAD binding
GO:0071276 cellular response to cadmium ion
GO:0071277 cellular response to calcium ion
GO:0071837 HMG box domain binding
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000144 positive regulation of DNA-templated transcription, initiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002112 Transcription factor JunFamilyFamily
IPR004827 Basic-leucine zipper domainDomainDomain
IPR005643 Jun-like transcription factorDomainDomain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR015558 Transcription Factor c-Jun/v-JunFamilyFamily

Diseases

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Interactions

34 interactions

InteractorPartnerSourcesPublicationsLink
JUN_MOUSEMK08_MOUSEBioGRID, MINT10581243 10748240 12223491 15218018 15288121 15767678 17158449 17255944 17276034 21538482 9687507 details
JUN_MOUSEFOS_MOUSEBioGRID, MINT12145309 15867431 1631061 21478324 details
JUN_MOUSEJUN_MOUSEBioGRID, MINT1631061 21262356 details
JUN_MOUSEESR1_HUMANUniProt11477071 details
JUN_MOUSEHHEX_MOUSEBioGRID11551904 details
JUN_MOUSEHXC8_MOUSEBioGRID11551904 details
JUN_MOUSEHXA9_MOUSEBioGRID11551904 details
JUN_MOUSEHME1_MOUSEBioGRID11551904 details
JUN_MOUSEATF4_MOUSEBioGRID20211142 details
JUN_MOUSEBARX2_MOUSEBioGRID20211142 details
JUN_MOUSEMAFB_MOUSEBioGRID12798298 20211142 details
JUN_MOUSESTAT3_MOUSEBioGRID20211142 details
JUN_MOUSESMAD3_MOUSEBioGRID22610349 details
JUN_MOUSECSN5_MOUSEBioGRID11704659 details
JUN_MOUSESNPC5_MOUSEBioGRID15867431 details
JUN_MOUSECASP9_MOUSEBioGRID23678002 details
JUN_MOUSEITB1_MOUSEBioGRID30333137 details
JUN_MOUSECDK6_MOUSEIntAct23948297 details
JUN_MOUSEATF3_MOUSEBioGRID, IntAct20211142 21304988 details
JUN_MOUSESMCA2_MOUSEBioGRID11053448 details
JUN_MOUSESNF5_MOUSEBioGRID11053448 details
JUN_MOUSEITCH_MOUSEBioGRID16901904 details
JUN_MOUSEESR1_MOUSEBioGRID19605792 details
JUN_MOUSEITF2_MOUSEBioGRID16007074 details
JUN_MOUSECTNB1_MOUSEBioGRID16007074 details
JUN_MOUSETF65_MOUSEBioGRID21262356 details
JUN_MOUSESP1_MOUSEBioGRID21262356 details
JUN_MOUSECREB1_MOUSEBioGRID21262356 details
JUN_MOUSECYLD_MOUSEBioGRID21478324 details
JUN_MOUSENUMB_HUMANBioGRID9632782 details
JUN_MOUSESIR1_MOUSEBioGRID18676681 20042607 details
JUN_MOUSEBRCA1_MOUSEBioGRID16807234 details
JUN_MOUSEBAG1_MOUSEBioGRID20516211 details
JUN_MOUSESPI1_MOUSEBioGRID19181746 details