Entity Details

Primary name K2C1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04264
EntryNameK2C1_HUMAN
FullNameKeratin, type II cytoskeletal 1
TaxID9606
Evidenceevidence at protein level
Length644
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesKRT1

GO terms

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GOName
GO:0001533 cornified envelope
GO:0001867 complement activation, lectin pathway
GO:0001895 retina homeostasis
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006979 response to oxidative stress
GO:0016020 membrane
GO:0018149 peptide cross-linking
GO:0030246 carbohydrate binding
GO:0030280 structural constituent of skin epidermis
GO:0031424 keratinization
GO:0038023 signaling receptor activity
GO:0042730 fibrinolysis
GO:0043312 neutrophil degranulation
GO:0045095 keratin filament
GO:0045765 regulation of angiogenesis
GO:0046982 protein heterodimerization activity
GO:0050728 negative regulation of inflammatory response
GO:0051290 protein heterotetramerization
GO:0061436 establishment of skin barrier
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0072562 blood microparticle
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003054 Keratin, type IIFamilyFamily
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR032444 Keratin type II headDomainDomain
IPR032449 Keratin type II cytoskeletal 1, tailDomainDomain
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule

Interactions

0 interactions

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