Entity Details

Primary name TBB4A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04350
EntryNameTBB4A_HUMAN
FullNameTubulin beta-4A chain
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesTUBB4A

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005930 axoneme
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0031115 negative regulation of microtubule polymerization
GO:0033269 internode region of axon
GO:0043025 neuronal cell body
GO:0043209 myelin sheath
GO:0070062 extracellular exosome
GO:0097711 ciliary basal body-plasma membrane docking

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000217 TubulinFamilyFamily
IPR002453 Beta tubulinFamilyFamily
IPR003008 Tubulin/FtsZ, GTPase domainDomainDomain
IPR008280 Tubulin/FtsZ, C-terminalFamilyHomologous superfamily
IPR013838 Beta tubulin, autoregulation binding siteSiteBinding site
IPR017975 Tubulin, conserved siteSiteConserved site
IPR018316 Tubulin/FtsZ, 2-layer sandwich domainDomainDomain
IPR023123 Tubulin, C-terminalFamilyHomologous superfamily
IPR036525 Tubulin/FtsZ, GTPase domain superfamilyFamilyHomologous superfamily
IPR037103 Tubulin/FtsZ-like, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01873 Epothilone DDrugbanksmall molecule
DB03010 PatupiloneDrugbanksmall molecule
DB05147 CYT997Drugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TBB4A_HUMANYAP1_MOUSEBioGRID30865227 details
TBB4A_HUMANHACD3_MOUSEIntAct25036637 details