Entity Details

Primary name HLAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04439
EntryNameHLAA_HUMAN
FullNameHLA class I histocompatibility antigen, A alpha chain
TaxID9606
Evidenceevidence at protein level
Length365
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesHLA-A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001913 T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
GO:0002726 positive regulation of T cell cytokine production
GO:0003723 RNA binding
GO:0005102 signaling receptor binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0009986 cell surface
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016032 viral process
GO:0016045 detection of bacterium
GO:0016567 protein ubiquitination
GO:0019731 antibacterial humoral response
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0030670 phagocytic vesicle membrane
GO:0030881 beta-2-microglobulin binding
GO:0031901 early endosome membrane
GO:0032729 positive regulation of interferon-gamma production
GO:0036037 CD8-positive, alpha-beta T cell activation
GO:0042270 protection from natural killer cell mediated cytotoxicity
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042605 peptide antigen binding
GO:0042608 T cell receptor binding
GO:0042610 CD8 receptor binding
GO:0042612 MHC class I protein complex
GO:0042824 MHC class I peptide loading complex
GO:0046977 TAP binding
GO:0050776 regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050852 T cell receptor signaling pathway
GO:0055038 recycling endosome membrane
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0062061 TAP complex binding
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation
GO:2000568 positive regulation of memory T cell activation
GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010579 MHC class I, alpha chain, C-terminalDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02740 3-Indolebutyric AcidDrugbanksmall molecule
DB06226 Nelipepimut-SDrugbankbiotech
DB11294 Coccidioides immitis spheruleDrugbankbiotech

Interactions

0 interactions

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