Entity Details

Primary name ERBB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04626
EntryNameERBB2_HUMAN
FullNameReceptor tyrosine-protein kinase erbB-2
TaxID9606
Evidenceevidence at protein level
Length1255
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesERBB2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001042 RNA polymerase I core binding
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007528 neuromuscular junction development
GO:0008022 protein C-terminus binding
GO:0008045 motor neuron axon guidance
GO:0008284 positive regulation of cell population proliferation
GO:0009925 basal plasma membrane
GO:0010008 endosome membrane
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0032886 regulation of microtubule-based process
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0033674 positive regulation of kinase activity
GO:0035556 intracellular signal transduction
GO:0038128 ERBB2 signaling pathway
GO:0038143 ERBB3:ERBB2 complex
GO:0042060 wound healing
GO:0042552 myelination
GO:0042802 identical protein binding
GO:0043125 ErbB-3 class receptor binding
GO:0043209 myelin sheath
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043547 positive regulation of GTPase activity
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0048709 oligodendrocyte differentiation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0071363 cellular response to growth factor stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:1901185 negative regulation of ERBB signaling pathway
GO:2000145 regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome
Nucleus

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR032778 Growth factor receptor domain 4DomainDomain
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00072 TrastuzumabDrugbankbiotech
DB01259 LapatinibDrugbanksmall molecule
DB04988 IGN311Drugbankbiotech
DB05773 Trastuzumab emtansineDrugbankbiotech
DB05944 VarlitinibDrugbanksmall molecule
DB06021 AV-412Drugbanksmall molecule
DB06366 PertuzumabDrugbankbiotech
DB08916 AfatinibDrugbanksmall molecule
DB11652 TucatinibDrugbanksmall molecule
DB11973 TesevatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB14967 MargetuximabDrugbankbiotech
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

3 interactions