Entity Details

Primary name LCK_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP06240
EntryNameLCK_MOUSE
FullNameProto-oncogene tyrosine-protein kinase LCK
TaxID10090
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesLck

GO terms

Show/Hide Table
GOName
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0003823 antigen binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008022 protein C-terminus binding
GO:0009612 response to mechanical stimulus
GO:0010038 response to metal ion
GO:0010628 positive regulation of gene expression
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030139 endocytic vesicle
GO:0030154 cell differentiation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0042169 SH2 domain binding
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042542 response to hydrogen peroxide
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0045589 regulation of regulatory T cell differentiation
GO:0046777 protein autophosphorylation
GO:0050853 B cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1990405 protein antigen binding
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035749 Lck, SH3 domainDomainDomain
IPR035850 Tyrosine-protein kinase Lck, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table