Entity Details

Primary name A4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05067
EntryNameA4_HUMAN
FullNameAmyloid-beta precursor protein
TaxID9606
Evidenceevidence at protein level
Length770
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesAPP

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001664 G protein-coupled receptor binding
GO:0001774 microglial cell activation
GO:0001878 response to yeast
GO:0001934 positive regulation of protein phosphorylation
GO:0001967 suckling behavior
GO:0002265 astrocyte activation involved in immune response
GO:0002576 platelet degranulation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005158 insulin receptor binding
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005769 early endosome
GO:0005788 endoplasmic reticulum lumen
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005796 Golgi lumen
GO:0005798 Golgi-associated vesicle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 clathrin-coated pit
GO:0005911 cell-cell junction
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006378 mRNA polyadenylation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0006878 cellular copper ion homeostasis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006897 endocytosis
GO:0006979 response to oxidative stress
GO:0007155 cell adhesion
GO:0007176 regulation of epidermal growth factor-activated receptor activity
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007219 Notch signaling pathway
GO:0007409 axonogenesis
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008088 axo-dendritic transport
GO:0008201 heparin binding
GO:0008203 cholesterol metabolic process
GO:0008285 negative regulation of cell population proliferation
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0009986 cell surface
GO:0009987 cellular process
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010823 negative regulation of mitochondrion organization
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014005 microglia development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016199 axon midline choice point recognition
GO:0016322 neuron remodeling
GO:0016358 dendrite development
GO:0016504 peptidase activator activity
GO:0019722 calcium-mediated signaling
GO:0019731 antibacterial humoral response
GO:0019732 antifungal humoral response
GO:0019899 enzyme binding
GO:0030111 regulation of Wnt signaling pathway
GO:0030134 COPII-coated ER to Golgi transport vesicle
GO:0030198 extracellular matrix organization
GO:0030424 axon
GO:0030546 signaling receptor activator activity
GO:0030549 acetylcholine receptor activator activity
GO:0030900 forebrain development
GO:0031093 platelet alpha granule lumen
GO:0031175 neuron projection development
GO:0031594 neuromuscular junction
GO:0031904 endosome lumen
GO:0032092 positive regulation of protein binding
GO:0032588 trans-Golgi network membrane
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032930 positive regulation of superoxide anion generation
GO:0032991 protein-containing complex
GO:0033130 acetylcholine receptor binding
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034185 apolipoprotein binding
GO:0034363 intermediate-density lipoprotein particle
GO:0034364 high-density lipoprotein particle
GO:0035066 positive regulation of histone acetylation
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035253 ciliary rootlet
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0040014 regulation of multicellular organism growth
GO:0042056 chemoattractant activity
GO:0042157 lipoprotein metabolic process
GO:0042327 positive regulation of phosphorylation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043395 heparan sulfate proteoglycan binding
GO:0043410 positive regulation of MAPK cascade
GO:0043525 positive regulation of neuron apoptotic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044304 main axon
GO:0045048 protein insertion into ER membrane
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0045202 synapse
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045821 positive regulation of glycolytic process
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046875 ephrin receptor binding
GO:0046914 transition metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048143 astrocyte activation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048669 collateral sprouting in absence of injury
GO:0048786 presynaptic active zone
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050750 low-density lipoprotein particle receptor binding
GO:0050786 RAGE receptor binding
GO:0050803 regulation of synapse structure or activity
GO:0050808 synapse organization
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050867 positive regulation of cell activation
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051087 chaperone binding
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051124 synaptic assembly at neuromuscular junction
GO:0051233 spindle midzone
GO:0051247 positive regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0051425 PTB domain binding
GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis
GO:0051897 positive regulation of protein kinase B signaling
GO:0055037 recycling endosome
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity
GO:0070062 extracellular exosome
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070381 endosome to plasma membrane transport vesicle
GO:0070555 response to interleukin-1
GO:0070851 growth factor receptor binding
GO:0071280 cellular response to copper ion
GO:0071287 cellular response to manganese ion
GO:0071320 cellular response to cAMP
GO:0071874 cellular response to norepinephrine stimulus
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090647 modulation of age-related behavioral decline
GO:0097449 astrocyte projection
GO:0097645 amylin binding
GO:0098815 modulation of excitatory postsynaptic potential
GO:0106003 amyloid-beta complex
GO:0150003 regulation of spontaneous synaptic transmission
GO:1900122 positive regulation of receptor binding
GO:1900181 negative regulation of protein localization to nucleus
GO:1900221 regulation of amyloid-beta clearance
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II
GO:1902949 positive regulation of tau-protein kinase activity
GO:1902950 regulation of dendritic spine maintenance
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1903048 regulation of acetylcholine-gated cation channel activity
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903523 negative regulation of blood circulation
GO:1904022 positive regulation of G protein-coupled receptor internalization
GO:1904399 heparan sulfate binding
GO:1904472 positive regulation of endothelin production
GO:1904591 positive regulation of protein import
GO:1904646 cellular response to amyloid-beta
GO:1905606 regulation of presynapse assembly
GO:1905893 positive regulation of cellular response to thapsigargin
GO:1905896 positive regulation of cellular response to tunicamycin
GO:1905898 positive regulation of response to endoplasmic reticulum stress
GO:1905906 regulation of amyloid fibril formation
GO:1905908 positive regulation of amyloid fibril formation
GO:1905945 regulation of response to calcium ion
GO:1990000 amyloid fibril formation
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990535 neuron projection maintenance
GO:1990761 growth cone lamellipodium
GO:1990777 lipoprotein particle
GO:1990812 growth cone filopodium
GO:2000310 regulation of NMDA receptor activity
GO:2000406 positive regulation of T cell migration
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cell surface
Cytoplasm
Cytoplasmic vesicle
Early endosome
Membrane
Nucleus
Perikaryon
Secreted

Domains

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DomainNameCategoryType
IPR002223 Pancreatic trypsin inhibitor Kunitz domainDomainDomain
IPR008154 Amyloidogenic glycoprotein, extracellularDomainDomain
IPR008155 Amyloidogenic glycoproteinFamilyFamily
IPR011178 Amyloidogenic glycoprotein, copper-bindingDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013803 Amyloidogenic glycoprotein, amyloid-beta peptideDomainDomain
IPR015849 Amyloidogenic glycoprotein, heparin-bindingDomainDomain
IPR019543 Beta-amyloid precursor protein C-terminalDomainDomain
IPR019744 Amyloidogenic glycoprotein, copper-binding domain conserved siteSiteConserved site
IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved siteSiteConserved site
IPR020901 Proteinase inhibitor I2, Kunitz, conserved siteSiteConserved site
IPR024329 Amyloidogenic glycoprotein, E2 domainDomainDomain
IPR028866 Amyloid-beta precursor proteinFamilyFamily
IPR036176 E2 domain superfamilyFamilyHomologous superfamily
IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamilyFamilyHomologous superfamily
IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamilyFamilyHomologous superfamily
IPR036880 Pancreatic trypsin inhibitor Kunitz domain superfamilyFamilyHomologous superfamily
IPR037071 Amyloidogenic glycoprotein, amyloid-beta peptide superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00746 DeferoxamineDrugbanksmall molecule
DB01370 AluminiumDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02235 L-methionine (R)-S-oxideDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03754 TromethamineDrugbanksmall molecule
DB04892 PhenserineDrugbanksmall molecule
DB05088 TetrathiomolybdateDrugbanksmall molecule
DB05150 CAD106Drugbanksmall molecule
DB05846 Mito-4509Drugbanksmall molecule
DB05938 EdonerpicDrugbanksmall molecule
DB06782 DimercaprolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09148 Florbetaben (18F)Drugbanksmall molecule
DB09149 Florbetapir (18F)Drugbanksmall molecule
DB09151 Flutemetamol (18F)Drugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14517 Aluminium phosphateDrugbanksmall molecule
DB14518 Aluminum acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule