Entity Details

Primary name IF2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05198
EntryNameIF2A_HUMAN
FullNameEukaryotic translation initiation factor 2 subunit 1
TaxID9606
Evidenceevidence at protein level
Length315
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesEIF2S1

GO terms

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GOName
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005844 polysome
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0005851 eukaryotic translation initiation factor 2B complex
GO:0006413 translational initiation
GO:0007568 aging
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0032057 negative regulation of translational initiation in response to stress
GO:0033290 eukaryotic 48S preinitiation complex
GO:0034063 stress granule assembly
GO:0034198 cellular response to amino acid starvation
GO:0034599 cellular response to oxidative stress
GO:0034605 cellular response to heat
GO:0034644 cellular response to UV
GO:0034976 response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0043022 ribosome binding
GO:0043614 multi-eIF complex
GO:0044207 translation initiation ternary complex
GO:0045202 synapse
GO:0046777 protein autophosphorylation
GO:0055085 transmembrane transport
GO:0070062 extracellular exosome
GO:0097451 glial limiting end-foot
GO:1901216 positive regulation of neuron death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:1990737 response to manganese-induced endoplasmic reticulum stress
GO:2000676 positive regulation of type B pancreatic cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003029 S1 domainDomainDomain
IPR011488 Translation initiation factor 2, alpha subunitFamilyFamily
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR022967 RNA-binding domain, S1DomainDomain
IPR024054 Translation initiation factor 2, alpha subunit, middle domain superfamilyFamilyHomologous superfamily
IPR024055 Translation initiation factor 2, alpha subunit, C-terminalFamilyHomologous superfamily
IPR044126 IF2a, S1-like domainDomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IF2A_HUMANE2AK3_MOUSEIntAct16288713 details