Entity Details

Primary name JUN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05412
EntryNameJUN_HUMAN
FullNameTranscription factor AP-1
TaxID9606
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesJUN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000228 nuclear chromosome
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001836 release of cytochrome c from mitochondria
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003723 RNA binding
GO:0005096 GTPase activator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007568 aging
GO:0007612 learning
GO:0007623 circadian rhythm
GO:0008134 transcription factor binding
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0032496 response to lipopolysaccharide
GO:0034097 response to cytokine
GO:0034614 cellular response to reactive oxygen species
GO:0035497 cAMP response element binding
GO:0035976 transcription factor AP-1 complex
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043392 negative regulation of DNA binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0043923 positive regulation by host of viral transcription
GO:0044389 ubiquitin-like protein ligase binding
GO:0044877 protein-containing complex binding
GO:0045657 positive regulation of monocyte differentiation
GO:0045740 positive regulation of DNA replication
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0051365 cellular response to potassium ion starvation
GO:0051591 response to cAMP
GO:0051726 regulation of cell cycle
GO:0051899 membrane depolarization
GO:0060395 SMAD protein signal transduction
GO:0070412 R-SMAD binding
GO:0071276 cellular response to cadmium ion
GO:0071837 HMG box domain binding
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000144 positive regulation of DNA-templated transcription, initiation

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002112 Transcription factor JunFamilyFamily
IPR004827 Basic-leucine zipper domainDomainDomain
IPR005643 Jun-like transcription factorDomainDomain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR015558 Transcription Factor c-Jun/v-JunFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00210 AdapaleneDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB01029 IrbesartanDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB05785 LGD-1550Drugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
JUN_HUMANMAZ_MOUSEIntAct19028685 details
JUN_HUMANSNF5_MOUSEBioGRID11053448 details
JUN_HUMANSMCA2_MOUSEBioGRID11053448 details