Entity Details

Primary name ITB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05556
EntryNameITB1_HUMAN
FullNameIntegrin beta-1
TaxID9606
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated1988-11-01
DateModified2021-06-02

Ontological Relatives

GenesITGB1

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0001618 virus receptor activity
GO:0001726 ruffle
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0003779 actin binding
GO:0005178 integrin binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006909 phagocytosis
GO:0006968 cellular defense response
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007161 calcium-independent cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010710 regulation of collagen catabolic process
GO:0010763 positive regulation of fibroblast migration
GO:0015026 coreceptor activity
GO:0016020 membrane
GO:0016477 cell migration
GO:0019058 viral life cycle
GO:0019221 cytokine-mediated signaling pathway
GO:0023035 CD40 signaling pathway
GO:0030027 lamellipodium
GO:0030030 cell projection organization
GO:0030032 lamellipodium assembly
GO:0030175 filopodium
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0031594 neuromuscular junction
GO:0031623 receptor internalization
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
GO:0033627 cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034665 integrin alpha1-beta1 complex
GO:0034666 integrin alpha2-beta1 complex
GO:0034667 integrin alpha3-beta1 complex
GO:0034668 integrin alpha4-beta1 complex
GO:0034674 integrin alpha5-beta1 complex
GO:0034678 integrin alpha8-beta1 complex
GO:0034680 integrin alpha10-beta1 complex
GO:0034681 integrin alpha11-beta1 complex
GO:0035633 maintenance of blood-brain barrier
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0043065 positive regulation of apoptotic process
GO:0043235 receptor complex
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045296 cadherin binding
GO:0045766 positive regulation of angiogenesis
GO:0046718 viral entry into host cell
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0048333 mesodermal cell differentiation
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051951 positive regulation of glutamate uptake involved in transmission of nerve impulse
GO:0055037 recycling endosome
GO:0070062 extracellular exosome
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090303 positive regulation of wound healing
GO:0097386 glial cell projection
GO:0098639 collagen binding involved in cell-matrix adhesion
GO:0150003 regulation of spontaneous synaptic transmission
GO:0150103 reactive gliosis
GO:1901979 regulation of inward rectifier potassium channel activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1990782 protein tyrosine kinase binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000811 negative regulation of anoikis

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cell surface
Cleavage furrow
Melanosome
Recycling endosome

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027071 Integrin beta-1 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB15791 MK-0668Drugbanksmall molecule