Entity Details

Primary name INSR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06213
EntryNameINSR_HUMAN
FullNameInsulin receptor
TaxID9606
Evidenceevidence at protein level
Length1382
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesINSR

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0002092 positive regulation of receptor internalization
GO:0003007 heart morphogenesis
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005159 insulin-like growth factor receptor binding
GO:0005198 structural molecule activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005764 lysosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0005901 caveola
GO:0005975 carbohydrate metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006898 receptor-mediated endocytosis
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007612 learning
GO:0007613 memory
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019087 transformation of host cell by virus
GO:0019904 protein domain specific binding
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032590 dendrite membrane
GO:0032809 neuronal cell body membrane
GO:0032869 cellular response to insulin stimulus
GO:0033674 positive regulation of kinase activity
GO:0038024 cargo receptor activity
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043410 positive regulation of MAPK cascade
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0044877 protein-containing complex binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045995 regulation of embryonic development
GO:0046326 positive regulation of glucose import
GO:0046777 protein autophosphorylation
GO:0048639 positive regulation of developmental growth
GO:0051425 PTB domain binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060267 positive regulation of respiratory burst
GO:0070062 extracellular exosome
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0150104 transport across blood-brain barrier
GO:1990535 neuron projection maintenance

Subcellular Location

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Subcellular Location
Cell membrane
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily
IPR040969 Insulin receptor, trans-membrane domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB01277 MecaserminDrugbankbiotech
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateDrugbanksmall molecule
DB05115 NN344Drugbanksmall molecule
DB05120 AT1391Drugbanksmall molecule
DB08513 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDDrugbanksmall molecule
DB09129 Chromic chlorideDrugbanksmall molecule
DB09564 Insulin degludecDrugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB14751 Mecasermin rinfabateDrugbankbiotech