Entity Details

Primary name LCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06239
EntryNameLCK_HUMAN
FullNameTyrosine-protein kinase Lck
TaxID9606
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesLCK

GO terms

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GOName
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008022 protein C-terminus binding
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0042169 SH2 domain binding
GO:0042493 response to drug
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051249 regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035749 Lck, SH3 domainDomainDomain
IPR035850 Tyrosine-protein kinase Lck, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB01830 AP-22408Drugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB04003 {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acidDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06925 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEDrugbanksmall molecule
DB07146 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINEDrugbanksmall molecule
DB07297 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINEDrugbanksmall molecule
DB08055 N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDrugbanksmall molecule
DB08056 N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDrugbanksmall molecule
DB08057 N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amineDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
LCK_HUMANMBP_MOUSEBioGRID, MINT18067320 details
LCK_HUMANCD3E_MOUSEBioGRID11855827 details
LCK_HUMAN3BP2_MOUSEMINT15751964 details