Entity Details

Primary name FYN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06241
EntryNameFYN_HUMAN
FullNameTyrosine-protein kinase Fyn
TaxID9606
Evidenceevidence at protein level
Length537
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesFYN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000304 response to singlet oxygen
GO:0001764 neuron migration
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003015 heart process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0007612 learning
GO:0007631 feeding behavior
GO:0008360 regulation of cell shape
GO:0010629 negative regulation of gene expression
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030425 dendrite
GO:0030900 forebrain development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0035556 intracellular signal transduction
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042542 response to hydrogen peroxide
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043274 phospholipase binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044297 cell body
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048813 dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050690 regulation of defense response to virus by virus
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050804 modulation of chemical synaptic transmission
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051428 peptide hormone receptor binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0070851 growth factor receptor binding
GO:0071375 cellular response to peptide hormone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:0097038 perinuclear endoplasmic reticulum
GO:0097062 dendritic spine maintenance
GO:0097386 glial cell projection
GO:0097718 disordered domain specific binding
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1900182 positive regulation of protein localization to nucleus
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1904645 response to amyloid-beta
GO:1904646 cellular response to amyloid-beta
GO:1905232 cellular response to L-glutamate
GO:1905430 cellular response to glycine
GO:1905477 positive regulation of protein localization to membrane
GO:1905664 regulation of calcium ion import across plasma membrane
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035750 Fyn/Yrk, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB02078 TriglymeDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule