Entity Details

Primary name AGAL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06280
EntryNameAGAL_HUMAN
FullNameAlpha-galactosidase A
TaxID9606
Evidenceevidence at protein level
Length429
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesGLA

GO terms

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GOName
GO:0003824 catalytic activity
GO:0004557 alpha-galactosidase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0006687 glycosphingolipid metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0016139 glycoside catabolic process
GO:0016787 hydrolase activity
GO:0017041 galactosylgalactosylglucosylceramidase activity
GO:0035578 azurophil granule lumen
GO:0042803 protein homodimerization activity
GO:0043202 lysosomal lumen
GO:0043312 neutrophil degranulation
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0046477 glycosylceramide catabolic process
GO:0046479 glycosphingolipid catabolic process
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0052692 raffinose alpha-galactosidase activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR000111 Glycoside hydrolase family 27/36, conserved siteSiteConserved site
IPR002241 Glycoside hydrolase, family 27FamilyFamily
IPR013780 Glycosyl hydrolase, all-betaFamilyHomologous superfamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR017853 Glycoside hydrolase superfamilyFamilyHomologous superfamily
IPR035373 Alpha galactosidase A, C-terminal beta-sandwich domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05018 MigalastatDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink