Entity Details

Primary name RB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06400
EntryNameRB_HUMAN
FullNameRetinoblastoma-associated protein
TaxID9606
Evidenceevidence at protein level
Length928
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesRB1

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001894 tissue homeostasis
GO:0003180 aortic valve morphogenesis
GO:0003714 transcription corepressor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005819 spindle
GO:0005829 cytosol
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0007076 mitotic chromosome condensation
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0016032 viral process
GO:0016514 SWI/SNF complex
GO:0016605 PML body
GO:0019900 kinase binding
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0031134 sister chromatid biorientation
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031175 neuron projection development
GO:0031625 ubiquitin protein ligase binding
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034349 glial cell apoptotic process
GO:0035189 Rb-E2F complex
GO:0035914 skeletal muscle cell differentiation
GO:0042551 neuron maturation
GO:0042802 identical protein binding
GO:0043353 enucleate erythrocyte differentiation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043550 regulation of lipid kinase activity
GO:0045445 myoblast differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048565 digestive tract development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051146 striated muscle cell differentiation
GO:0051219 phosphoprotein binding
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0061676 importin-alpha family protein binding
GO:0071459 protein localization to chromosome, centromeric region
GO:0071466 cellular response to xenobiotic stimulus
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071922 regulation of cohesin loading
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0090230 regulation of centromere complex assembly
GO:0097284 hepatocyte apoptotic process
GO:0097718 disordered domain specific binding
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1902948 negative regulation of tau-protein kinase activity
GO:1903055 positive regulation of extracellular matrix organization
GO:1904028 positive regulation of collagen fibril organization
GO:1904761 negative regulation of myofibroblast differentiation
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002719 Retinoblastoma-associated protein, B-boxDomainDomain
IPR002720 Retinoblastoma-associated protein, A-boxDomainDomain
IPR013763 Cyclin-likeDomainDomain
IPR015030 Retinoblastoma-associated protein, C-terminalDomainDomain
IPR024599 Retinoblastoma-associated protein, N-terminalDomainDomain
IPR028309 Retinoblastoma protein familyFamilyFamily
IPR036915 Cyclin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech