Entity Details

Primary name PRGR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06401
EntryNamePRGR_HUMAN
FullNameProgesterone receptor
TaxID9606
Evidenceevidence at protein level
Length933
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesPGR

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001542 ovulation from ovarian follicle
GO:0002070 epithelial cell maturation
GO:0003677 DNA binding
GO:0003707 steroid hormone receptor activity
GO:0004879 nuclear receptor activity
GO:0005102 signaling receptor binding
GO:0005496 steroid binding
GO:0005654 nucleoplasm
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008270 zinc ion binding
GO:0010629 negative regulation of gene expression
GO:0019899 enzyme binding
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0038001 paracrine signaling
GO:0042802 identical protein binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048286 lung alveolus development
GO:0050678 regulation of epithelial cell proliferation
GO:0050847 progesterone receptor signaling pathway
GO:0051117 ATPase binding
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000128 Progesterone receptorFamilyFamily
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00294 EtonogestrelDrugbanksmall molecule
DB00304 DesogestrelDrugbanksmall molecule
DB00351 Megestrol acetateDrugbanksmall molecule
DB00367 LevonorgestrelDrugbanksmall molecule
DB00378 DydrogesteroneDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB00588 Fluticasone propionateDrugbanksmall molecule
DB00603 Medroxyprogesterone acetateDrugbanksmall molecule
DB00648 MitotaneDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00764 MometasoneDrugbanksmall molecule
DB00823 Ethynodiol diacetateDrugbanksmall molecule
DB00834 MifepristoneDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB01395 DrospirenoneDrugbanksmall molecule
DB01406 DanazolDrugbanksmall molecule
DB01428 OxybenzoneDrugbanksmall molecule
DB01431 AllylestrenolDrugbanksmall molecule
DB02746 Phthalic AcidDrugbanksmall molecule
DB02998 MetriboloneDrugbanksmall molecule
DB04787 TanaprogetDrugbanksmall molecule
DB05253 Telapristone acetateDrugbanksmall molecule
DB06680 AsoprisnilDrugbanksmall molecule
DB06713 NorelgestrominDrugbanksmall molecule
DB06730 GestodeneDrugbanksmall molecule
DB06789 Hydroxyprogesterone caproateDrugbanksmall molecule
DB08867 UlipristalDrugbanksmall molecule
DB08906 Fluticasone furoateDrugbanksmall molecule
DB09123 DienogestDrugbanksmall molecule
DB09124 MedrogestoneDrugbanksmall molecule
DB09389 NorgestrelDrugbanksmall molecule
DB11064 HomosalateDrugbanksmall molecule
DB11219 EnzacameneDrugbanksmall molecule
DB11619 GestrinoneDrugbanksmall molecule
DB12941 DarolutamideDrugbanksmall molecule
DB13857 DemegestoneDrugbanksmall molecule
DB13867 FluticasoneDrugbanksmall molecule
DB14512 Mometasone furoateDrugbanksmall molecule
DB14583 Segesterone acetateDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PRGR_HUMANNCOA2_MOUSEBioGRID10757795 details