Entity Details

Primary name CDK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06493
EntryNameCDK1_HUMAN
FullNameCyclin-dependent kinase 1
TaxID9606
Evidenceevidence at protein level
Length297
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesCDK1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000781 chromosome, telomeric region
GO:0001618 virus receptor activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007076 mitotic chromosome condensation
GO:0007077 mitotic nuclear membrane disassembly
GO:0007084 mitotic nuclear membrane reassembly
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007098 centrosome cycle
GO:0007344 pronuclear fusion
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014038 regulation of Schwann cell differentiation
GO:0016020 membrane
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030332 cyclin binding
GO:0030496 midbody
GO:0030855 epithelial cell differentiation
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0034501 protein localization to kinetochore
GO:0035173 histone kinase activity
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0045995 regulation of embryonic development
GO:0048511 rhythmic process
GO:0051301 cell division
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070062 extracellular exosome
GO:0070371 ERK1 and ERK2 cascade
GO:0072686 mitotic spindle
GO:0090166 Golgi disassembly
GO:0097125 cyclin B1-CDK1 complex
GO:0097472 cyclin-dependent protein kinase activity
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB02052 Indirubin-3'-monoximeDrugbanksmall molecule
DB02116 OlomoucineDrugbanksmall molecule
DB02950 HymenialdisineDrugbanksmall molecule
DB03428 SU9516Drugbanksmall molecule
DB03496 AlvocidibDrugbanksmall molecule
DB04014 AlsterpaulloneDrugbanksmall molecule
DB06195 SeliciclibDrugbanksmall molecule
DB08142 AT-7519Drugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule