Entity Details

Primary name IF4E_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06730
EntryNameIF4E_HUMAN
FullNameEukaryotic translation initiation factor 4E
TaxID9606
Evidenceevidence at protein level
Length217
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesEIF4E

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000339 RNA cap binding
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0001662 behavioral fear response
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005845 mRNA cap binding complex
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0010494 cytoplasmic stress granule
GO:0016032 viral process
GO:0016281 eukaryotic translation initiation factor 4F complex
GO:0016442 RISC complex
GO:0017148 negative regulation of translation
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030324 lung development
GO:0031370 eukaryotic initiation factor 4G binding
GO:0033391 chromatoid body
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045665 negative regulation of neuron differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0071549 cellular response to dexamethasone stimulus
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001040 Translation Initiation factor eIF- 4eFamilyFamily
IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved siteSiteConserved site
IPR023398 Translation Initiation factor eIF- 4e-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01649 7-methyl-GpppADrugbanksmall molecule
DB01960 7-methyl-7,8-dihydroguanosine-5'-diphosphateDrugbanksmall molecule
DB02716 7-methyl-guanosine-5'-triphosphateDrugbanksmall molecule
DB05165 LY2275796Drugbanksmall molecule
DB08217 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioateDrugbanksmall molecule