Entity Details

Primary name NPM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06748
EntryNameNPM_HUMAN
FullNameNucleophosmin
TaxID9606
Evidenceevidence at protein level
Length294
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesNPM1

GO terms

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GOName
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0001046 core promoter sequence-specific DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0004860 protein kinase inhibitor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006281 DNA repair
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006407 rRNA export from nucleus
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007098 centrosome cycle
GO:0007165 signal transduction
GO:0007569 cell aging
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0010824 regulation of centrosome duplication
GO:0010826 negative regulation of centrosome duplication
GO:0016020 membrane
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030957 Tat protein binding
GO:0031616 spindle pole centrosome
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0034080 CENP-A containing nucleosome assembly
GO:0034644 cellular response to UV
GO:0042255 ribosome assembly
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0042393 histone binding
GO:0042803 protein homodimerization activity
GO:0043023 ribosomal large subunit binding
GO:0043024 ribosomal small subunit binding
GO:0043066 negative regulation of apoptotic process
GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045727 positive regulation of translation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046599 regulation of centriole replication
GO:0051059 NF-kappaB binding
GO:0051082 unfolded protein binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060699 regulation of endoribonuclease activity
GO:0060735 regulation of eIF2 alpha phosphorylation by dsRNA
GO:1902629 regulation of mRNA stability involved in cellular response to UV
GO:1902751 positive regulation of cell cycle G2/M phase transition
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004301 Nucleoplasmin familyFamilyFamily
IPR024057 Nucleoplasmin core domainDomainDomain
IPR032569 Nucleophosmin, C-terminalDomainDomain
IPR036824 Nucleoplasmin core domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB11638 ArtenimolDrugbanksmall molecule

Interactions

4 interactions