Entity Details

Primary name FES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07332
EntryNameFES_HUMAN
FullNameTyrosine-protein kinase Fes/Fps
TaxID9606
Evidenceevidence at protein level
Length822
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesFES

GO terms

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GOName
GO:0001578 microtubule bundle formation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0006935 chemotaxis
GO:0007098 centrosome cycle
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008017 microtubule binding
GO:0008360 regulation of cell shape
GO:0010976 positive regulation of neuron projection development
GO:0015630 microtubule cytoskeleton
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0031116 positive regulation of microtubule polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0034987 immunoglobulin receptor binding
GO:0035091 phosphatidylinositol binding
GO:0042127 regulation of cell population proliferation
GO:0043304 regulation of mast cell degranulation
GO:0045087 innate immune response
GO:0045595 regulation of cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0046777 protein autophosphorylation
GO:0060627 regulation of vesicle-mediated transport
GO:0071305 cellular response to vitamin D
GO:2000145 regulation of cell motility
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001060 FCH domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016250 Tyrosine-protein kinase, Fes/Fps typeFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027267 AH/BAR domain superfamilyFamilyHomologous superfamily
IPR031160 F-BAR domainDomainDomain
IPR035849 Fes/Fps/Fer, SH2 domainDomainDomain
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FES_HUMANBCAR1_MOUSEBioGRID8999909 details