Entity Details

Primary name TBB5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07437
EntryNameTBB5_HUMAN
FullNameTubulin beta chain
TaxID9606
Evidenceevidence at protein level
Length444
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesTUBB

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0003924 GTPase activity
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0007017 microtubule-based process
GO:0009987 cellular process
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019904 protein domain specific binding
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031625 ubiquitin protein ligase binding
GO:0032794 GTPase activating protein binding
GO:0032991 protein-containing complex
GO:0035578 azurophil granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042288 MHC class I protein binding
GO:0043312 neutrophil degranulation
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0050807 regulation of synapse organization
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0070062 extracellular exosome
GO:0097711 ciliary basal body-plasma membrane docking

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000217 TubulinFamilyFamily
IPR002453 Beta tubulinFamilyFamily
IPR003008 Tubulin/FtsZ, GTPase domainDomainDomain
IPR008280 Tubulin/FtsZ, C-terminalFamilyHomologous superfamily
IPR013838 Beta tubulin, autoregulation binding siteSiteBinding site
IPR017975 Tubulin, conserved siteSiteConserved site
IPR018316 Tubulin/FtsZ, 2-layer sandwich domainDomainDomain
IPR023123 Tubulin, C-terminalFamilyHomologous superfamily
IPR036525 Tubulin/FtsZ, GTPase domain superfamilyFamilyHomologous superfamily
IPR037103 Tubulin/FtsZ-like, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00361 VinorelbineDrugbanksmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB01179 PodofiloxDrugbanksmall molecule
DB01394 ColchicineDrugbanksmall molecule
DB01873 Epothilone DDrugbanksmall molecule
DB03010 PatupiloneDrugbanksmall molecule
DB05147 CYT997Drugbanksmall molecule
DB05284 CA4PDrugbanksmall molecule
DB06042 ZEN-012Drugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule
DB11641 VinflunineDrugbanksmall molecule
DB11731 Depatuxizumab mafodotinDrugbankbiotech
DB12334 MilataxelDrugbanksmall molecule
DB15534 ColchiceineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
TBB5_HUMANYAP1_MOUSEBioGRID30865227 details