Entity Details

Primary name PROF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07737
EntryNamePROF1_HUMAN
FullNameProfilin-1
TaxID9606
Evidenceevidence at protein level
Length140
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPFN1

GO terms

Show/Hide Table
GOName
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0045296 cadherin binding
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0072562 blood microparticle
GO:1900029 positive regulation of ruffle assembly

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR005454 Profilin1/2/3, vertebrateFamilyFamily
IPR005455 ProfilinFamilyFamily
IPR027310 Profilin conserved siteSiteConserved site
IPR029892 Profilin-1FamilyFamily
IPR036140 Profilin superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARINDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PROF1_HUMANDIAP1_MOUSEmbinfo9214622 details
PROF1_HUMANMK13_MOUSEBioGRID19135240 details