Entity Details

Primary name HS90A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07900
EntryNameHS90A_HUMAN
FullNameHeat shock protein HSP 90-alpha
TaxID9606
Evidenceevidence at protein level
Length732
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesHSP90AA1

GO terms

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GOName
GO:0002230 positive regulation of defense response to virus by host
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0009408 response to heat
GO:0009409 response to cold
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019221 cytokine-mediated signaling pathway
GO:0030911 TPR domain binding
GO:0032273 positive regulation of protein polymerization
GO:0034774 secretory granule lumen
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043312 neutrophil degranulation
GO:0046677 response to antibiotic
GO:0051131 chaperone-mediated protein complex assembly
GO:0070062 extracellular exosome
GO:0098586 cellular response to virus
GO:1904813 ficolin-1-rich granule lumen
GO:0000086 G2/M transition of mitotic cell cycle
GO:0002218 activation of innate immune response
GO:0005829 cytosol
GO:0006898 receptor-mediated endocytosis
GO:0006986 response to unfolded protein
GO:0016032 viral process
GO:0032728 positive regulation of interferon-beta production
GO:0032991 protein-containing complex
GO:0038128 ERBB2 signaling pathway
GO:0042026 protein refolding
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0043202 lysosomal lumen
GO:0043209 myelin sheath
GO:0043335 protein unfolding
GO:0044183 protein folding chaperone
GO:0044294 dendritic growth cone
GO:0045040 protein insertion into mitochondrial outer membrane
GO:0048471 perinuclear region of cytoplasm
GO:0051020 GTPase binding
GO:0061684 chaperone-mediated autophagy
GO:0070182 DNA polymerase binding
GO:0071682 endocytic vesicle lumen
GO:0097110 scaffold protein binding
GO:1903364 positive regulation of cellular protein catabolic process
GO:1905323 telomerase holoenzyme complex assembly
GO:0001934 positive regulation of protein phosphorylation
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0021955 central nervous system neuron axonogenesis
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0043025 neuronal cell body
GO:0043254 regulation of protein-containing complex assembly
GO:0044295 axonal growth cone
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046146 tetrahydrobiopterin metabolic process
GO:0048675 axon extension
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051973 positive regulation of telomerase activity
GO:0060544 regulation of necroptotic process
GO:1900034 regulation of cellular response to heat
GO:1902949 positive regulation of tau-protein kinase activity
GO:1903827 regulation of cellular protein localization
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006457 protein folding
GO:0006839 mitochondrial transport
GO:0007004 telomere maintenance via telomerase
GO:0016020 membrane
GO:0016887 ATP hydrolysis activity
GO:0023026 MHC class II protein complex binding
GO:0030010 establishment of cell polarity
GO:0030235 nitric-oxide synthase regulator activity
GO:0031396 regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0034605 cellular response to heat
GO:0042981 regulation of apoptotic process
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048156 tau protein binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0097711 ciliary basal body-plasma membrane docking
GO:0097718 disordered domain specific binding
GO:1990782 protein tyrosine kinase binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Cell membrane
Melanosome
Nucleus

Domains

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DomainNameCategoryType
IPR001404 Heat shock protein Hsp90 familyFamilyFamily
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR019805 Heat shock protein Hsp90, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR020575 Heat shock protein Hsp90, N-terminalDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR037196 HSP90, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00615 RifabutinDrugbanksmall molecule
DB00716 NedocromilDrugbanksmall molecule
DB02359 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-YlamineDrugbanksmall molecule
DB02424 GeldanamycinDrugbanksmall molecule
DB02550 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-YlamineDrugbanksmall molecule
DB02754 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-AmineDrugbanksmall molecule
DB02840 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic AcidDrugbanksmall molecule
DB03093 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-YlamineDrugbanksmall molecule
DB03137 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-YlamineDrugbanksmall molecule
DB03504 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-YlamineDrugbanksmall molecule
DB03749 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-PyrazoleDrugbanksmall molecule
DB03809 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-AmineDrugbanksmall molecule
DB03899 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-AmineDrugbanksmall molecule
DB04054 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-YlamineDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04254 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-YlamineDrugbanksmall molecule
DB04505 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-YlamineDrugbanksmall molecule
DB04588 N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDEDrugbanksmall molecule
DB05134 TanespimycinDrugbanksmall molecule
DB06070 SNX-5422Drugbanksmall molecule
DB06956 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDEDrugbanksmall molecule
DB06957 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB06958 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDEDrugbanksmall molecule
DB06961 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamideDrugbanksmall molecule
DB06964 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDEDrugbanksmall molecule
DB06969 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamideDrugbanksmall molecule
DB07100 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOLDrugbanksmall molecule
DB07317 (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-oneDrugbanksmall molecule
DB07319 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINEDrugbanksmall molecule
DB07324 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONEDrugbanksmall molecule
DB07325 N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDEDrugbanksmall molecule
DB07495 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDEDrugbanksmall molecule
DB07502 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diolDrugbanksmall molecule
DB07594 CCT-018159Drugbanksmall molecule
DB07601 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diolDrugbanksmall molecule
DB07877 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINEDrugbanksmall molecule
DB08194 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amineDrugbanksmall molecule
DB08197 (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oximeDrugbanksmall molecule
DB08436 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-Drugbanksmall molecule
DB08442 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diolDrugbanksmall molecule
DB08443 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triolDrugbanksmall molecule
DB08557 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamideDrugbanksmall molecule
DB08786 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amineDrugbanksmall molecule
DB08787 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amineDrugbanksmall molecule
DB08788 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDEDrugbanksmall molecule
DB08789 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDEDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB12442 AlvespimycinDrugbanksmall molecule