Entity Details

Primary name YES_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07947
EntryNameYES_HUMAN
FullNameTyrosine-protein kinase Yes
TaxID9606
Evidenceevidence at protein level
Length543
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesYES1

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006464 cellular protein modification process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0019899 enzyme binding
GO:0030154 cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043114 regulation of vascular permeability
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0048013 ephrin receptor signaling pathway
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035751 Tyrosine-protein kinase Yes, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
YES_HUMANCTNB1_MOUSEMINT12640114 details
YES_HUMANMBP_MOUSEBioGRID, MINT18067320 details