Entity Details

Primary name LYN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07948
EntryNameLYN_HUMAN
FullNameTyrosine-protein kinase Lyn
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesLYN

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002553 histamine secretion by mast cell
GO:0002576 platelet degranulation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006991 response to sterol depletion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016301 kinase activity
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0030061 mitochondrial crista
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032868 response to insulin
GO:0033003 regulation of mast cell activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0034666 integrin alpha2-beta1 complex
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043015 gamma-tubulin binding
GO:0043200 response to amino acid
GO:0043208 glycosphingolipid binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043304 regulation of mast cell degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045646 regulation of erythrocyte differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048678 response to axon injury
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051219 phosphoprotein binding
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060252 positive regulation of glial cell proliferation
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070062 extracellular exosome
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0071300 cellular response to retinoic acid
GO:0090025 regulation of monocyte chemotaxis
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:0140031 phosphorylation-dependent protein binding
GO:1902532 negative regulation of intracellular signal transduction
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:2000670 positive regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035748 Tyrosine-protein kinase Lyn, SH3 domainDomainDomain
IPR035852 Tyrosine-protein kinase Lyn, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule