Entity Details

Primary name RET_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07949
EntryNameRET_HUMAN
FullNameProto-oncogene tyrosine-protein kinase receptor Ret
TaxID9606
Evidenceevidence at protein level
Length1114
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesRET

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001657 ureteric bud development
GO:0001755 neural crest cell migration
GO:0001838 embryonic epithelial tube formation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007158 neuron cell-cell adhesion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007497 posterior midgut development
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014042 positive regulation of neuron maturation
GO:0030155 regulation of cell adhesion
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0033619 membrane protein proteolysis
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0035799 ureter maturation
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
GO:0038023 signaling receptor activity
GO:0042493 response to drug
GO:0042551 neuron maturation
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0045121 membrane raft
GO:0045793 positive regulation of cell size
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048265 response to pain
GO:0048484 enteric nervous system development
GO:0050770 regulation of axonogenesis
GO:0051897 positive regulation of protein kinase B signaling
GO:0060041 retina development in camera-type eye
GO:0060384 innervation
GO:0061146 Peyer's patch morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0072300 positive regulation of metanephric glomerulus development
GO:0097021 lymphocyte migration into lymphoid organs
GO:0098797 plasma membrane protein complex
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002126 Cadherin-likeDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015919 Cadherin-like superfamilyFamilyHomologous superfamily
IPR016249 Tyrosine-protein kinase, Ret receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR040667 Tyrosine-protein kinase receptor Ret, cadherin like domain 3DomainDomain
IPR041163 Ret, cadherin like domain 1DomainDomain
IPR041317 RET cadherin-like domain 4DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00398 SorafenibDrugbanksmall molecule
DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule
DB15685 SelpercatinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
RET_HUMANPLCG1_MOUSEMINT8662982 details
RET_HUMANSHC1_MOUSEBioGRID10995764 details