Entity Details

Primary name IGF1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08069
EntryNameIGF1R_HUMAN
FullNameInsulin-like growth factor 1 receptor
TaxID9606
Evidenceevidence at protein level
Length1367
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesIGF1R

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005009 insulin-activated receptor activity
GO:0005010 insulin-like growth factor-activated receptor activity
GO:0005158 insulin receptor binding
GO:0005198 structural molecule activity
GO:0005520 insulin-like growth factor binding
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005899 insulin receptor complex
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016032 viral process
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0031994 insulin-like growth factor I binding
GO:0033674 positive regulation of kinase activity
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043410 positive regulation of MAPK cascade
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043559 insulin binding
GO:0043560 insulin receptor substrate binding
GO:0045056 transcytosis
GO:0046328 regulation of JNK cascade
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051389 obsolete inactivation of MAPKK activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0071333 cellular response to glucose stimulus
GO:0097062 dendritic spine maintenance
GO:0097242 amyloid-beta clearance
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140318 protein transporter activity
GO:1902911 protein kinase complex
GO:1904646 cellular response to amyloid-beta

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000494 Receptor L-domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR002011 Tyrosine-protein kinase, receptor class II, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR006211 Furin-like cysteine-rich domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016246 Tyrosine-protein kinase, insulin-like receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036941 Receptor L-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00030 Insulin humanDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB01277 MecaserminDrugbankbiotech
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB05023 ATL1101Drugbanksmall molecule
DB05184 XL228Drugbanksmall molecule
DB05897 rhIGFBP-3Drugbanksmall molecule
DB06075 LinsitinibDrugbanksmall molecule
DB06343 TeprotumumabDrugbankbiotech
DB07156 (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dioneDrugbanksmall molecule
DB07474 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONEDrugbanksmall molecule
DB09098 SomatremDrugbankbiotech
DB09564 Insulin degludecDrugbankbiotech
DB12250 CixutumumabDrugbankbiotech
DB12267 BrigatinibDrugbanksmall molecule
DB14751 Mecasermin rinfabateDrugbankbiotech