Entity Details

Primary name HS90B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08238
EntryNameHS90B_HUMAN
FullNameHeat shock protein HSP 90-beta
TaxID9606
Evidenceevidence at protein level
Length724
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesHSP90AB1

GO terms

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GOName
GO:0001890 placenta development
GO:0002134 UTP binding
GO:0002135 CTP binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006457 protein folding
GO:0006805 xenobiotic metabolic process
GO:0006986 response to unfolded protein
GO:0007004 telomere maintenance via telomerase
GO:0009651 response to salt stress
GO:0009986 cell surface
GO:0016020 membrane
GO:0016234 inclusion body
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016887 ATP hydrolysis activity
GO:0017098 sulfonylurea receptor binding
GO:0019062 virion attachment to host cell
GO:0019887 protein kinase regulator activity
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0021955 central nervous system neuron axonogenesis
GO:0023026 MHC class II protein complex binding
GO:0030010 establishment of cell polarity
GO:0030235 nitric-oxide synthase regulator activity
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030911 TPR domain binding
GO:0031072 heat shock protein binding
GO:0031396 regulation of protein ubiquitination
GO:0031526 brush border membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032564 dATP binding
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034605 cellular response to heat
GO:0034751 aryl hydrocarbon receptor complex
GO:0034774 secretory granule lumen
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042220 response to cocaine
GO:0042277 peptide binding
GO:0042307 positive regulation of protein import into nucleus
GO:0042470 melanosome
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0043008 ATP-dependent protein binding
GO:0043025 neuronal cell body
GO:0043312 neutrophil degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0044183 protein folding chaperone
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0044325 transmembrane transporter binding
GO:0045296 cadherin binding
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045793 positive regulation of cell size
GO:0046983 protein dimerization activity
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048675 axon extension
GO:0050821 protein stabilization
GO:0051082 unfolded protein binding
GO:0051131 chaperone-mediated protein complex assembly
GO:0051248 negative regulation of protein metabolic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0051973 positive regulation of telomerase activity
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070182 DNA polymerase binding
GO:0071353 cellular response to interleukin-4
GO:0071407 cellular response to organic cyclic compound
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0097435 supramolecular fiber organization
GO:0097718 disordered domain specific binding
GO:0120293 dynein axonemal particle
GO:1900034 regulation of cellular response to heat
GO:1901389 negative regulation of transforming growth factor beta activation
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:1902949 positive regulation of tau-protein kinase activity
GO:1903660 negative regulation of complement-dependent cytotoxicity
GO:1903827 regulation of cellular protein localization
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
GO:1904813 ficolin-1-rich granule lumen
GO:1905323 telomerase holoenzyme complex assembly
GO:1990226 histone methyltransferase binding
GO:1990565 HSP90-CDC37 chaperone complex
GO:1990913 sperm head plasma membrane
GO:1990917 ooplasm
GO:2000010 positive regulation of protein localization to cell surface

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Dynein axonemal particle
Melanosome
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001404 Heat shock protein Hsp90 familyFamilyFamily
IPR003594 Histidine kinase/HSP90-like ATPaseDomainDomain
IPR019805 Heat shock protein Hsp90, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR020575 Heat shock protein Hsp90, N-terminalDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR037196 HSP90, C-terminal domainFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02424 GeldanamycinDrugbanksmall molecule
DB02754 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-AmineDrugbanksmall molecule
DB03758 RadicicolDrugbanksmall molecule
DB05134 TanespimycinDrugbanksmall molecule
DB06070 SNX-5422Drugbanksmall molecule
DB07594 CCT-018159Drugbanksmall molecule
DB07877 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINEDrugbanksmall molecule
DB08045 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOLDrugbanksmall molecule
DB08153 (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONEDrugbanksmall molecule
DB08292 (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONEDrugbanksmall molecule
DB08293 (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONEDrugbanksmall molecule
DB08346 (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONEDrugbanksmall molecule
DB08464 METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATEDrugbanksmall molecule
DB08465 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATEDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule

Interactions

3 interactions