Entity Details

Primary name GCR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP06537
EntryNameGCR_MOUSE
FullNameGlucocorticoid receptor
TaxID10090
Evidenceevidence at protein level
Length783
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004879 nuclear receptor activity
GO:0004883 glucocorticoid receptor activity
GO:0005496 steroid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0006111 regulation of gluconeogenesis
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0008211 glucocorticoid metabolic process
GO:0008270 zinc ion binding
GO:0010906 regulation of glucose metabolic process
GO:0014049 positive regulation of glutamate secretion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0030325 adrenal gland development
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030544 Hsp70 protein binding
GO:0030971 receptor tyrosine kinase binding
GO:0031072 heat shock protein binding
GO:0031914 negative regulation of synaptic plasticity
GO:0031946 regulation of glucocorticoid biosynthetic process
GO:0032991 protein-containing complex
GO:0042127 regulation of cell population proliferation
GO:0042562 hormone binding
GO:0042711 maternal behavior
GO:0042802 identical protein binding
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043116 negative regulation of vascular permeability
GO:0043197 dendritic spine
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046685 response to arsenic-containing substance
GO:0048096 chromatin-mediated maintenance of transcription
GO:0051879 Hsp90 protein binding
GO:0060603 mammary gland duct morphogenesis
GO:0060999 positive regulation of dendritic spine development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0071383 cellular response to steroid hormone stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component
GO:1900170 negative regulation of glucocorticoid mediated signaling pathway
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990239 steroid hormone binding
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000324 positive regulation of glucocorticoid receptor signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001409 Glucocorticoid receptorFamilyFamily
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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