Entity Details

Primary name MET_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08581
EntryNameMET_HUMAN
FullNameHepatocyte growth factor receptor
TaxID9606
Evidenceevidence at protein level
Length1390
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesMET

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001886 endothelial cell morphogenesis
GO:0001889 liver development
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005008 hepatocyte growth factor-activated receptor activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0010507 negative regulation of autophagy
GO:0016021 integral component of membrane
GO:0016477 cell migration
GO:0017154 semaphorin receptor activity
GO:0019903 protein phosphatase binding
GO:0030182 neuron differentiation
GO:0031016 pancreas development
GO:0031116 positive regulation of microtubule polymerization
GO:0033674 positive regulation of kinase activity
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035635 entry of bacterium into host cell
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050918 positive chemotaxis
GO:0051497 negative regulation of stress fiber assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0061436 establishment of skin barrier
GO:0070495 negative regulation of thrombin-activated receptor signaling pathway
GO:0071526 semaphorin-plexin signaling pathway
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity
GO:2001028 positive regulation of endothelial cell chemotaxis

Subcellular Location

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Subcellular Location
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001627 Sema domainDomainDomain
IPR002165 Plexin repeatRepeatRepeat
IPR002909 IPT domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR016244 Tyrosine-protein kinase, HGF/MSP receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR031148 Plexin familyFamilyFamily
IPR036352 Sema domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02152 K-252aDrugbanksmall molecule
DB06314 SGX-523Drugbanksmall molecule
DB06896 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamideDrugbanksmall molecule
DB06995 N-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamideDrugbanksmall molecule
DB06997 2-(4-fluorophenyl)-N-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamideDrugbanksmall molecule
DB07369 N-(3-chlorophenyl)-N-methyl-2-oxo-3-[(3,4,5-trimethyl-1H-pyrrol-2-yl)methyl]-2H-indole-5-sulfonamideDrugbanksmall molecule
DB07969 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenolDrugbanksmall molecule
DB08079 AMG-208Drugbanksmall molecule
DB08791 1-[(2-NITROPHENYL)SULFONYL]-1H-PYRROLO[3,2-B]PYRIDINE-6-CARBOXAMIDEDrugbanksmall molecule
DB08865 CrizotinibDrugbanksmall molecule
DB08875 CabozantinibDrugbanksmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12200 TivantinibDrugbanksmall molecule
DB12267 BrigatinibDrugbanksmall molecule
DB12742 AmuvatinibDrugbanksmall molecule

Interactions

4 interactions