Entity Details

Primary name HCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08631
EntryNameHCK_HUMAN
FullNameTyrosine-protein kinase HCK
TaxID9606
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesHCK

GO terms

Show/Hide Table
GOName
GO:0001784 phosphotyrosine residue binding
GO:0002522 leukocyte migration involved in immune response
GO:0002758 innate immune response-activating signal transduction
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007498 mesoderm development
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030133 transport vesicle
GO:0030154 cell differentiation
GO:0030838 positive regulation of actin filament polymerization
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043299 leukocyte degranulation
GO:0045087 innate immune response
GO:0045728 respiratory burst after phagocytosis
GO:0046777 protein autophosphorylation
GO:0050690 regulation of defense response to virus by virus
GO:0050727 regulation of inflammatory response
GO:0050764 regulation of phagocytosis
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0071801 regulation of podosome assembly
GO:2000251 positive regulation of actin cytoskeleton reorganization

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus
Lysosome
Membrane
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035851 Tyrosine-protein kinase HCK, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01809 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB01962 PhosphonotyrosineDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HCK_HUMANMBP_MOUSEBioGRID, MINT18067320 details
HCK_HUMANCBL_MOUSEIntAct10092522 details