Entity Details

Primary name PGFRB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09619
EntryNamePGFRB_HUMAN
FullNamePlatelet-derived growth factor receptor beta
TaxID9606
Evidenceevidence at protein level
Length1106
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPDGFRB

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004992 platelet activating factor receptor activity
GO:0005017 platelet-derived growth factor-activated receptor activity
GO:0005019 platelet-derived growth factor beta-receptor activity
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006024 glycosaminoglycan biosynthetic process
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007568 aging
GO:0008284 positive regulation of cell population proliferation
GO:0008584 male gonad development
GO:0009636 response to toxic substance
GO:0009986 cell surface
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019838 growth factor binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030335 positive regulation of cell migration
GO:0031226 intrinsic component of plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0032355 response to estradiol
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032526 response to retinoic acid
GO:0032956 regulation of actin cytoskeleton organization
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033674 positive regulation of kinase activity
GO:0034405 response to fluid shear stress
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035441 cell migration involved in vasculogenesis
GO:0035789 metanephric mesenchymal cell migration
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
GO:0035909 aorta morphogenesis
GO:0038085 vascular endothelial growth factor binding
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0042060 wound healing
GO:0042542 response to hydrogen peroxide
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043202 lysosomal lumen
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043627 response to estrogen
GO:0045840 positive regulation of mitotic nuclear division
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048146 positive regulation of fibroblast proliferation
GO:0048407 platelet-derived growth factor binding
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048839 inner ear development
GO:0050921 positive regulation of chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
GO:0055003 cardiac myofibril assembly
GO:0055093 response to hyperoxia
GO:0060326 cell chemotaxis
GO:0060437 lung growth
GO:0060981 cell migration involved in coronary angiogenesis
GO:0061298 retina vasculature development in camera-type eye
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071670 smooth muscle cell chemotaxis
GO:0072075 metanephric mesenchyme development
GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development
GO:0072277 metanephric glomerular capillary formation
GO:0072278 metanephric comma-shaped body morphogenesis
GO:0072284 metanephric S-shaped body morphogenesis
GO:0090280 positive regulation of calcium ion import
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasmic vesicle
Lysosome lumen

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027288 Platelet-derived growth factor receptor betaFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00102 BecaplerminDrugbankbiotech
DB00398 SorafenibDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB05014 XL999Drugbanksmall molecule
DB05146 XL820Drugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB08896 RegorafenibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB09221 PolaprezincDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule
DB14840 RipretinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PGFRB_HUMANVGFR2_MOUSEDIP18997771 details