Entity Details

Primary name PARP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09874
EntryNamePARP1_HUMAN
FullNamePoly [ADP-ribose] polymerase 1
TaxID9606
Evidenceevidence at protein level
Length1014
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPARP1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000715 nucleotide-excision repair, DNA damage recognition
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0006281 DNA repair
GO:0006287 base-excision repair, gap-filling
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302 double-strand break repair
GO:0006366 transcription by RNA polymerase II
GO:0006471 protein ADP-ribosylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007005 mitochondrion organization
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0010332 response to gamma radiation
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010990 regulation of SMAD protein complex assembly
GO:0016020 membrane
GO:0016540 protein autoprocessing
GO:0016604 nuclear body
GO:0018312 peptidyl-serine ADP-ribosylation
GO:0018424 peptidyl-glutamic acid poly-ADP-ribosylation
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030225 macrophage differentiation
GO:0030331 estrogen receptor binding
GO:0030592 DNA ADP-ribosylation
GO:0032042 mitochondrial DNA metabolic process
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034599 cellular response to oxidative stress
GO:0034644 cellular response to UV
GO:0035861 site of double-strand break
GO:0036211 protein modification process
GO:0042769 DNA damage response, detection of DNA damage
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043504 mitochondrial DNA repair
GO:0044030 regulation of DNA methylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0050790 regulation of catalytic activity
GO:0051287 NAD binding
GO:0051901 positive regulation of mitochondrial depolarization
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0070212 protein poly-ADP-ribosylation
GO:0070213 protein auto-ADP-ribosylation
GO:0070412 R-SMAD binding
GO:0070911 global genome nucleotide-excision repair
GO:0071294 cellular response to zinc ion
GO:0090734 site of DNA damage
GO:0140294 NAD DNA ADP-ribosyltransferase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1901216 positive regulation of neuron death
GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903518 positive regulation of single strand break repair
GO:1903827 regulation of cellular protein localization
GO:1904044 response to aldosterone
GO:1904357 negative regulation of telomere maintenance via telomere lengthening
GO:1904646 cellular response to amyloid-beta
GO:1904762 positive regulation of myofibroblast differentiation
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:1990404 protein ADP-ribosylase activity
GO:1990966 ATP generation from poly-ADP-D-ribose
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001170 negative regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001357 BRCT domainDomainDomain
IPR001510 Zinc finger, PARP-typeDomainDomain
IPR004102 Poly(ADP-ribose) polymerase, regulatory domainDomainDomain
IPR008288 Poly [ADP-ribose] polymeraseFamilyFamily
IPR008893 WGR domainDomainDomain
IPR012317 Poly(ADP-ribose) polymerase, catalytic domainDomainDomain
IPR012982 PADR1 domainDomainDomain
IPR036420 BRCT domain superfamilyFamilyHomologous superfamily
IPR036616 Poly(ADP-ribose) polymerase, regulatory domain superfamilyFamilyHomologous superfamily
IPR036930 WGR domain superfamilyFamilyHomologous superfamily
IPR036957 Zinc finger, PARP-type superfamilyFamilyHomologous superfamily
IPR038650 PADR1 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00277 TheophyllineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB02498 Carba-nicotinamide-adenine-dinucleotideDrugbanksmall molecule
DB02690 NU1025Drugbanksmall molecule
DB02701 NicotinamideDrugbanksmall molecule
DB03072 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-QuinazolinoneDrugbanksmall molecule
DB03073 3-MethoxybenzamideDrugbanksmall molecule
DB03509 2-(4-Chlorophenyl)-5-QuinoxalinecarboxamideDrugbanksmall molecule
DB03722 3,4-Dihydro-5-Methyl-IsoquinolinoneDrugbanksmall molecule
DB04010 2-(3'-Methoxyphenyl) Benzimidazole-4-CarboxamideDrugbanksmall molecule
DB07096 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONEDrugbanksmall molecule
DB07232 VeliparibDrugbanksmall molecule
DB07330 A-620223Drugbanksmall molecule
DB07787 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONEDrugbanksmall molecule
DB09074 OlaparibDrugbanksmall molecule
DB11760 TalazoparibDrugbanksmall molecule
DB11793 NiraparibDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB13877 IniparibDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule