Entity Details

Primary name FURIN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09958
EntryNameFURIN_HUMAN
FullNameFurin
TaxID9606
Evidenceevidence at protein level
Length794
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFURIN

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001825 blastocyst formation
GO:0002020 protease binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006465 signal peptide processing
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008233 peptidase activity
GO:0009966 regulation of signal transduction
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0019058 viral life cycle
GO:0019082 viral protein processing
GO:0022617 extracellular matrix disassembly
GO:0030140 trans-Golgi network transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0030198 extracellular matrix organization
GO:0030574 collagen catabolic process
GO:0031638 zymogen activation
GO:0032374 regulation of cholesterol transport
GO:0032455 nerve growth factor processing
GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process
GO:0032902 nerve growth factor production
GO:0032911 negative regulation of transforming growth factor beta1 production
GO:0032940 secretion by cell
GO:0042176 regulation of protein catabolic process
GO:0042277 peptide binding
GO:0043043 peptide biosynthetic process
GO:0045121 membrane raft
GO:0046872 metal ion binding
GO:0048406 nerve growth factor binding
GO:0051004 regulation of lipoprotein lipase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0052548 regulation of endopeptidase activity
GO:0070062 extracellular exosome
GO:0070268 cornification
GO:0090472 dibasic protein processing
GO:0097341 zymogen inhibition
GO:1901394 positive regulation of transforming growth factor beta1 activation
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Cell membrane
Endosome membrane
Golgi apparatus
Secreted

Domains

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DomainNameCategoryType
IPR000209 Peptidase S8/S53 domainDomainDomain
IPR002884 P domainDomainDomain
IPR006212 Furin-like repeatRepeatRepeat
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR015500 Peptidase S8, subtilisin-relatedFamilyFamily
IPR022398 Peptidase S8, subtilisin, His-active siteSiteActive site
IPR023827 Peptidase S8, subtilisin, Asp-active siteSiteActive site
IPR023828 Peptidase S8, subtilisin, Ser-active siteSiteActive site
IPR032815 Peptidase S8, pro-domainDomainDomain
IPR034182 Kexin/furin catalytic domainDomainDomain
IPR036852 Peptidase S8/S53 domain superfamilyFamilyHomologous superfamily
IPR038466 Peptidase S8, pro-domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB03600 Capric acidDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
FURIN_HUMANGDF11_MOUSEDIP18378898 details
FURIN_HUMANFLNA_MOUSEBioGRID9412467 details