Entity Details

Primary name TNFA_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP06804
EntryNameTNFA_MOUSE
FullNameTumor necrosis factor
TaxID10090
Evidenceevidence at protein level
Length235
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesTnf

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000185 obsolete activation of MAPKKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0000976 transcription cis-regulatory region binding
GO:0001774 microglial cell activation
GO:0001775 cell activation
GO:0001819 positive regulation of cytokine production
GO:0001891 phagocytic cup
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002020 protease binding
GO:0002037 negative regulation of L-glutamate import across plasma membrane
GO:0002269 leukocyte activation involved in inflammatory response
GO:0002439 chronic inflammatory response to antigenic stimulus
GO:0002637 regulation of immunoglobulin production
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006006 glucose metabolic process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007254 JNK cascade
GO:0007275 multicellular organism development
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009615 response to virus
GO:0009887 animal organ morphogenesis
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010033 response to organic substance
GO:0010459 negative regulation of heart rate
GO:0010573 vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019722 calcium-mediated signaling
GO:0030141 secretory granule
GO:0030198 extracellular matrix organization
GO:0030316 osteoclast differentiation
GO:0030730 sequestering of triglyceride
GO:0030866 cortical actin cytoskeleton organization
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031622 positive regulation of fever generation
GO:0031642 negative regulation of myelination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032715 negative regulation of interleukin-6 production
GO:0032722 positive regulation of chemokine production
GO:0032724 positive regulation of fractalkine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032741 positive regulation of interleukin-18 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034138 toll-like receptor 3 signaling pathway
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0042127 regulation of cell population proliferation
GO:0042311 vasodilation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0043243 positive regulation of protein-containing complex disassembly
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043507 positive regulation of JUN kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045071 negative regulation of viral genome replication
GO:0045121 membrane raft
GO:0045123 cellular extravasation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045760 positive regulation of action potential
GO:0045785 positive regulation of cell adhesion
GO:0045840 positive regulation of mitotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045994 positive regulation of translational initiation by iron
GO:0046325 negative regulation of glucose import
GO:0046330 positive regulation of JNK cascade
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
GO:0048566 embryonic digestive tract development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050708 regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050796 regulation of insulin secretion
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050830 defense response to Gram-positive bacterium
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050995 negative regulation of lipid catabolic process
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0051222 positive regulation of protein transport
GO:0051384 response to glucocorticoid
GO:0051798 positive regulation of hair follicle development
GO:0051897 positive regulation of protein kinase B signaling
GO:0055037 recycling endosome
GO:0060252 positive regulation of glial cell proliferation
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060693 regulation of branching involved in salivary gland morphogenesis
GO:0061044 negative regulation of vascular wound healing
GO:0061048 negative regulation of branching involved in lung morphogenesis
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071230 cellular response to amino acid stimulus
GO:0071316 cellular response to nicotine
GO:0071407 cellular response to organic cyclic compound
GO:0071803 positive regulation of podosome assembly
GO:0072577 endothelial cell apoptotic process
GO:0072659 protein localization to plasma membrane
GO:0090324 negative regulation of oxidative phosphorylation
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097527 necroptotic signaling pathway
GO:0120190 negative regulation of bile acid secretion
GO:0150129 positive regulation of interleukin-33 production
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900222 negative regulation of amyloid-beta clearance
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901647 positive regulation of synoviocyte proliferation
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902004 positive regulation of amyloid-beta formation
GO:1902565 positive regulation of neutrophil activation
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903140 regulation of establishment of endothelial barrier
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903347 negative regulation of bicellular tight junction assembly
GO:1903721 positive regulation of I-kappaB phosphorylation
GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell
GO:2000010 positive regulation of protein localization to cell surface
GO:2000272 negative regulation of signaling receptor activity
GO:2000334 positive regulation of blood microparticle formation
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001272 positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Subcellular Location

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Subcellular Location
Cell membrane
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR002959 Tumour necrosis factor alphaFamilyFamily
IPR006052 Tumour necrosis factor domainDomainDomain
IPR006053 Tumour necrosis factorFamilyFamily
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site

Diseases

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