Entity Details

Primary name CALM1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP0DP23
EntryNameCALM1_HUMAN
FullNameCalmodulin-1
TaxID9606
Evidenceevidence at protein level
Length149
SequenceStatuscomplete
DateCreated2017-05-10
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0000922 spindle pole
GO:0001975 response to amphetamine
GO:0002027 regulation of heart rate
GO:0002576 platelet degranulation
GO:0005509 calcium ion binding
GO:0005513 detection of calcium ion
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005876 spindle microtubule
GO:0005886 plasma membrane
GO:0005980 glycogen catabolic process
GO:0006936 muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007268 chemical synaptic transmission
GO:0008076 voltage-gated potassium channel complex
GO:0008179 adenylate cyclase binding
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010856 adenylate cyclase activator activity
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016032 viral process
GO:0016240 autophagosome membrane docking
GO:0019855 calcium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021762 substantia nigra development
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030017 sarcomere
GO:0030234 enzyme regulator activity
GO:0030235 nitric-oxide synthase regulator activity
GO:0030426 growth cone
GO:0030672 synaptic vesicle membrane
GO:0031432 titin binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031954 positive regulation of protein autophosphorylation
GO:0031966 mitochondrial membrane
GO:0031982 vesicle
GO:0031997 N-terminal myristoylation domain binding
GO:0032465 regulation of cytokinesis
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032991 protein-containing complex
GO:0034704 calcium channel complex
GO:0035307 positive regulation of protein dephosphorylation
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043209 myelin sheath
GO:0043388 positive regulation of DNA binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043647 inositol phosphate metabolic process
GO:0044325 transmembrane transporter binding
GO:0046146 tetrahydrobiopterin metabolic process
GO:0048306 calcium-dependent protein binding
GO:0050998 nitric-oxide synthase binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051412 response to corticosterone
GO:0051592 response to calcium ion
GO:0055117 regulation of cardiac muscle contraction
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072542 protein phosphatase activator activity
GO:0090151 establishment of protein localization to mitochondrial membrane
GO:0097718 disordered domain specific binding
GO:0098901 regulation of cardiac muscle cell action potential
GO:0140056 organelle localization by membrane tethering
GO:1900242 regulation of synaptic vesicle endocytosis
GO:1901842 negative regulation of high voltage-gated calcium channel activity
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1902494 catalytic complex
GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00477 ChlorpromazineDrugbanksmall molecule
DB00527 CinchocaineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00831 TrifluoperazineDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB01373 CalciumDrugbanksmall molecule
DB01429 AprindineDrugbanksmall molecule
DB02868 DeacetoxyvinzolidineDrugbanksmall molecule
DB03900 tert-butanolDrugbanksmall molecule
DB03977 TrimethyllysineDrugbanksmall molecule
DB04513 N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideDrugbanksmall molecule
DB04825 PrenylamineDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB08039 (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13800 Calcium levulinateDrugbanksmall molecule
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule

Interactions

3 interactions